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Inhibitory effect of cyclosporin A on prolactin synthesis in GH3 cells
http://hdl.handle.net/2297/16858
http://hdl.handle.net/2297/1685861dae080-6795-4f6d-b91e-f7fa05b682f0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-TAKAMURA-T-337.pdf (1.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Inhibitory effect of cyclosporin A on prolactin synthesis in GH3 cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Nagai, Yukihiro
× Nagai, Yukihiro× Ohsawa, Kensou× Ohta, Masayoshi× Hisada, Azusa× Yamashita, Haruhisa× Yoshizawa, Miyako× Yamamoto, Yasuhiko× Takamura, Toshinari× Kobayashi, Kenichi |
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| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||
| 書誌情報 |
Tohoku Journal of Experimental Medicine 巻 180, 号 4, p. 337-346, 発行日 1996-12-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0040-8727 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1620/tjem.180.337 | |||||
| 出版者 | ||||||
| 出版者 | 東北大学 : 東北ジャーナル刊行会 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cyclosporin A (CsA), a potent immunosuppressant, is known to have various effects on the endocrine system, including the pituitary gland, the adrenal cortex, the testes, and the pancreatic islets. In this study, the effects of CsA on prolactin (PRL) synthesis and release were investigated in GH3 cells, a clonal strain of rat pituitary tumor. After incubation of confluent GH3 cells with various concentrations of CsA for 24 hr, the PRL content of the media decreased in a dose-dependent manner: by 28.5% with 100 ng/ml CsA (p < 0.01); and 45.8% with 2,000 ng/ml CsA (p < 0.001), compared with control. However, no significant change was observed in the intracellular PRL content. After removal of CsA from the medium, GH3 cells fully recovered normal secretory activity within 24-48 hr, thus indicating that the inhibitory effect of CsA on PRL secretion was reversible. Northern blot analysis revealed a decrease in the PRL mRNA level in cells treated with CsA. In conclusion, these data suggest that CsA inhibits PRL secretion by reducing the rate of biosynthesis. A possible site of action is on PRL gene expression at the level of mRNA transcription. | |||||
| 権利 | ||||||
| 権利情報 | Copyright (c) 2006 Tohoku University Medical Press | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1620/tjem.180.337 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.jstage.jst.go.jp/article/tjem/180/4/180_337/_article | |||||
