WEKO3
アイテム
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.
http://hdl.handle.net/2297/19337
http://hdl.handle.net/2297/1933711708b77-c5ce-4221-9c6a-7fde059aa875
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-WAKAYAMA-T-1088.pdf (827.2 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Inomata, Ken
× Inomata, Ken× Aoto, Takahiro× Binh, Nguyen Thanh× Okamoto, Natsuko× Tanimura, Shintaro× Wakayama, Tomohiko× Iseki, Shoichi× Hara, Eiji× Masunaga, Takuji× Shimizu, Hiroshi× Nishimura, Emi K. |
|||||
| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学医薬保健研究域 医学系 | |||||
| 書誌情報 |
Cell 巻 137, 号 6, p. 1088-1099, 発行日 2009-06-01 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0092-8674 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00600003 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.cell.2009.03.037 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier (Cell Press) | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Somatic stem cell depletion due to the accumulation of DNA damage has been implicated in the appearance of aging-related phenotypes. Hair graying, a typical sign of aging in mammals, is caused by the incomplete maintenance of melanocyte stem cells (MSCs) with age. Here, we report that irreparable DNA damage, as caused by ionizing radiation, abrogates renewal of MSCs in mice. Surprisingly, the DNA-damage response triggers MSC differentiation into mature melanocytes in the niche, rather than inducing their apoptosis or senescence. The resulting MSC depletion leads to irreversible hair graying. Furthermore, deficiency of Ataxia-telangiectasia mutated (ATM), a central transducer kinase of the DNA-damage response, sensitizes MSCs to ectopic differentiation, demonstrating that the kinase protects MSCs from their premature differentiation by functioning as a "stemness checkpoint" to maintain the stem cell quality and quantity. © 2009 Elsevier Inc. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.elsevier.com/locate/issn/00928674 | |||||
