| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-03 |
| タイトル |
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|
タイトル |
Biological safety of nasal thallium-201 administration: A preclinical study for olfacto-scintigraphy |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00013484 |
|
ID登録タイプ |
JaLC |
| 著者 |
Washiyama, Kohshin
Shiga, Hideaki
Hirota, Kyoko
Tsuchida, Asuka
Yamamoto, Junpei
Yagi, Sayaka
Yoshizaki, Tomokazu
Furukawa, Mitsuru
Amano, Ryohei
Miwa, Takaki
|
| 著者別表示 |
鷲山, 幸信
志賀, 英明
吉崎, 智一
古川, 仞
天野, 良平
三輪, 高喜
|
| 書誌情報 |
Journal of Radiation Research
巻 52,
号 4,
p. 450-455,
発行日 2011-01-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0449-3060 |
| NCID |
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識別子タイプ |
NCID |
|
|
関連識別子 |
BA58077230 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1269/jrr.10153 |
| 出版者 |
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出版者 |
Japan Radiation Research Society = 日本放射線影響学会 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Nasal administration of thallium-201 (201Tl) has previously been shown to be useful for the assessment of olfactory nerve connectivity in vivo. We assessed the biological effects of nasal 201Tl administration in mice to determine its safety before conducting clinical trials on humans. 201Tl uptake was evaluated in normal mice (n = 5) in vivo by using a high-resolution gamma camera and radiography 15 min, 1, 2 and 9 d after administration of 201TlCl to the right side of the nasal cavity (10 μl 201TlCl per nostril, 74 MBq/ml). Murine olfactory epithelial thickness (n = 5) was measured 9 d following nasal administration of 201TlCl. We assessed the odor detection ability of normal mice (n = 8) following nasal administration of 201TlCl to both sides of the nasal cavity, by observing cycloheximide solution avoidance behavior. We subsequently administrated 201TlCl (n = 4) or saline (n = 4) to both nostrils to assess the odor detection ability of mice following bilateral olfactory nerve transection. 201Tl uptake by the nasal cavity decreased immediately following nasal administration of 201Tl in normal mice. Nasal administration of 201Tl did not affect the olfactory epithelial thickness or the odor detection ability of normal mice. Recovery of odor detection ability following olfactory nerve transection was not significantly different between mice nasally administered with 201Tl, and mice administered with saline. Thus, nasal administration of 201Tl for the diagnosis of traumatic olfactory impairment did not produce harmful biological effects in vivo. |
| 権利 |
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|
権利情報 |
Copyright (c) 2011 by Journal of Radiation Research Editorial Committee |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
|
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|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.jstage.jst.go.jp/article/jrr/52/4/52_450/_article |
| 関連URI |
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|
識別子タイプ |
URI |
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|
関連識別子 |
http://web.me.com/jrred/JRR/index.html |
| 関連URI |
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|
識別子タイプ |
URI |
|
|
関連識別子 |
https://japanlinkcenter.org/JST.JSTAGE/jrr/10153 |
ME-PR-WASHIYAMA-K-450.pdf (791.8 kB)
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