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A novel y chromosome microdeletion with the loss of an endogenous retrovirus related, testis specific transcript in AZFb region
http://hdl.handle.net/2297/29470
http://hdl.handle.net/2297/2947049faf3a5-0a0f-4f25-9608-7f17295b9696
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-KOH-E-1545.pdf (1.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | A novel y chromosome microdeletion with the loss of an endogenous retrovirus related, testis specific transcript in AZFb region | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Sin, Ho-Su
× Sin, Ho-Su× Koh, Eitetsu× Taya, Masaki× IIjima, Masashi× Sugimoto, Kazuhiro× Maeda, Yuji× Yoshida, Atsumi× Iwamoto, Teruaki× Namiki, Mikio |
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| 書誌情報 |
Journal of Urology 巻 186, 号 4, p. 1545-1552, 発行日 2011-10-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0022-5347 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00708666 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.juro.2011.05.044 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier B.V. / American Urological Association (AUA) | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: We identified the endogenous retroviruses associated with TTYs (testis specific transcripts linked to the Y) in the AZFb region. We evaluated the relationship between endogenous retroviruses, and TTY expression patterns and function in spermatogenesis. Materials and Methods: We identified family members of TTYs in the AZFb region using computational screening. After investigating the relationship between the endogenous retrovirus genome and TTY expression patterns we screened genomic polymerase chain reaction products from TTY13 amplified from 790 Japanese men, including 275 with azoospermia, 285 with oligozoospermia and 230 who were fertile. Results: Computational screening revealed that 3 members of the TTY family, TTY9, 10 and 13, were regulated by endogenous retroviruses in the AZFb region. Homologous recombination between long terminal repeat of the TTY13 associated human endogenous retrovirus-K14C resulted in TTY13 deletion events. These deletions were more common in patients with azoospermia and oligozoospermia than in fertile males. Specifically 15.63% of the azoospermia group, 10.88% of the oligozoospermia group and 0% of fertile controls had only the deletion variant, indicating an association between the homologous recombination rate and the severity of spermatogenesis failure that was statistically significant (p <0.05). Conclusions: Because of the finding of what are to our knowledge novel microdeletions due to endogenous retrovirus in the AZFb region, our study raises the possibility that specific variations in genomic structure may contribute to some forms of human idiopathic male infertility. © 2011 American Urological Association Education and Research, Inc. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.jurology.com/ | |||||
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| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.elsevier.com/locate/issn/00225347 | |||||
