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High cortisol and cortisone levels are associated with breast milk dioxin concentrations in Vietnamese women
http://hdl.handle.net/2297/36471
http://hdl.handle.net/2297/3647153720735-c143-4f83-b721-767ae68eb208
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-KIDO-T-131.pdf (460.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | High cortisol and cortisone levels are associated with breast milk dioxin concentrations in Vietnamese women | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kido, Teruhiko
× Kido, Teruhiko× Tung, Dao Van× Manh, Ho Dung× Nhu, Dang Duc× Ngoc, Pham Thien× Naganuma, Rie× Tai, Pham The× Maruzeni, Shoko× Nishijo, Muneko× Nakagawa, Hideaki× Honma, Seijiro× Son, Le Ke× Hung, Nguyen Ngoc |
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| 書誌情報 |
European Journal of Endocrinology 巻 170, 号 1, p. 131-139, 発行日 2014-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0804-4643 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10991304 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1530/EJE-13-0410 | |||||
| 出版者 | ||||||
| 出版者 | European Society of Endocrinology / BioScientifica | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: Dioxin (polychlorinated dibenzodioxins Cpolychlorinated dibenzofurans) is one of the most toxic chemical substances known. Although it is suspected to cause endocrine disruption, very few epidemiological studies have been carried out on its effects on human steroid hormones. The aim of this study was to elucidate the association of dioxin exposure with steroid hormone levels in the saliva and serum of Vietnamese women. Study design : Two areas, namely Phu Cat (hot spot) and Kim Bang (nonexposed area), were selected for the study. The study subjects consisted of 51 and 58 women respectively. Saliva, blood, and breast milk samples were collected from the subjects in both the areas. Methods: Cortisol, cortisone, DHEA, androstenedione, estrone, and estradiol levels in serum and saliva were determined by liquid chromatography-tandem mass spectrometry; dioxin concentrations in breast milk were measured by gas chromatography-mass spectrometry. Results: Dioxin concentrations in the breast milk of women from the dioxin hot spot were three to four times higher than those in the breast milk of women from the nonexposed area. Good correlations were found between the levels of six steroid hormones in saliva and those in serum respectively. Salivary and serum cortisol and cortisone levels in women from the dioxin hot spot were significantly higher than those in women from the nonexposed area (P<0.001) and those in all the subjects were positively associated with dioxin concentrations in Vietnamese women (P<0.01). Conclusion: These results suggest that dioxin influences steroidogenesis in humans. Saliva samples can be used for hormone analysis and are therefore excellent specimens in epidemiological studies. © 2014 European Society of Endocrinology. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
