{"_buckets": {"deposit": "c49d0544-70bd-4696-b029-8e85c662d040"}, "_deposit": {"created_by": 3, "id": "13716", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "13716"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00013716", "sets": ["1134"]}, "author_link": ["21843", "100", "109534", "20135", "193", "1822", "52", "11684", "22962", "2474", "20132", "80168", "22945", "78955", "81107", "12082", "22961", "43"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-01-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "720", "bibliographicPageStart": "709", "bibliographicVolumeNumber": "28", "bibliographic_titles": [{"bibliographic_title": "Journal of Alzheimer\u0027s Disease"}]}]}, "item_4_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "杉原, 崇大"}], "nameIdentifiers": [{"nameIdentifier": "109534", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "棟居, 聖一"}], "nameIdentifiers": [{"nameIdentifier": "2474", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "10399040", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=10399040"}]}, {"creatorNames": [{"creatorName": "山本, 靖彦"}], "nameIdentifiers": [{"nameIdentifier": "100", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20313637", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20313637"}, {"nameIdentifier": "20313637", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=20313637"}, {"nameIdentifier": "20313637", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000020313637"}]}, {"creatorNames": [{"creatorName": "櫻井, 繁"}], "nameIdentifiers": [{"nameIdentifier": "20135", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60332665", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60332665"}, {"nameIdentifier": "60332665", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000060332665"}]}, {"creatorNames": [{"creatorName": "北村, 暘二"}], "nameIdentifiers": [{"nameIdentifier": "80168", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "10368483", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=10368483"}]}, {"creatorNames": [{"creatorName": "柴, 和弘"}], "nameIdentifiers": [{"nameIdentifier": "43", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40143929", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40143929"}, {"nameIdentifier": "40143929", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=40143929"}, {"nameIdentifier": "40143929", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000040143929"}]}, {"creatorNames": [{"creatorName": "渡邊, 拓夫"}], "nameIdentifiers": [{"nameIdentifier": "193", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40303268", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40303268"}, {"nameIdentifier": "40303268", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000040303268"}]}, {"creatorNames": [{"creatorName": "米倉, 秀人"}], "nameIdentifiers": [{"nameIdentifier": "78955", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80240373", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80240373"}]}, {"creatorNames": [{"creatorName": "林, 靖彦"}], "nameIdentifiers": [{"nameIdentifier": "1822", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50324124", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50324124"}]}, {"creatorNames": [{"creatorName": "濱田, 潤一郎"}], "nameIdentifiers": [{"nameIdentifier": "81107", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40253752", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40253752"}]}, {"creatorNames": [{"creatorName": "山本, 博"}], "nameIdentifiers": [{"nameIdentifier": "52", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00115198", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00115198"}, {"nameIdentifier": "00115198", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000000115198"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The cell-surface receptor for advanced glycation end-products (RAGE) has been implicated in the development of diabetic vascular complications and Alzheimer\u0027s disease. RAGE has been considered to be involved in amyloid-β 1-42 (Aβ 1-42) uptake into brain. In the present study, we demonstrate that endogenous secretory RAGE (esRAGE), a decoy form of RAGE generated by alternative RNA processing, is able to inhibit Aβ 1-42 influx into mouse brain. Surface plasmon resonance and competitive binding assays revealed that human Aβ 1-42 interacted with human esRAGE within the immunoglobulin V type region. We next examined the uptake and distribution of 125I-labeled human Aβ 1-42 in various organs and body fluids of newly created mice overexpressing human esRAGE as well as RAGE-null and wild-type (WT) mice. The transition of the 125I-labeled Aβ 1-42 from circulation to brain parenchyma peaked at 30 min after the injection into WT mice, but this was significantly blunted in esRAGE-overexpressing and RAGE-null mice. Significant reduction in 125I-labeled Aβ 1-42-derived photo-stimulated luminescence were marked in ventricles, cerebral cortex, hippocampus, especially CA1 and CA3 regions, putamen, and thalamus. The results thus suggest the potential of esRAGE in protection against the development of Alzheimer\u0027s disease. © 2012 - IOS Press and the authors. All rights reserved.", "subitem_description_type": "Abstract"}]}, "item_4_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Thesis of Sugihara Takahiro / 学位論文 医学甲第2227 杉原 崇大", "subitem_description_type": "Other"}]}, "item_4_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00013703", "subitem_identifier_reg_type": "JaLC"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "IOS Press"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3233/JAD-2011-110776", "subitem_relation_type_select": "DOI"}}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11545428", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": 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