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統合失調症モデルラットにおける免疫組織化学染色法を用いたCaMKII活性イメージング法
http://hdl.handle.net/2297/37260
http://hdl.handle.net/2297/37260f19a400d-363c-48c0-bb7f-ce7b2f1d36a6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-TADANO-T-501.pdf (501.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | 統合失調症モデルラットにおける免疫組織化学染色法を用いたCaMKII活性イメージング法 | |||||
| タイトル | ||||||
| タイトル | Imaging Monitoring Method of CaMKII Activity by Immunohistochemical Analysis in Schizophrenic Model Rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
矢吹, 悌
× 矢吹, 悌× 中川西, 修× 只野, 武× 福永, 浩司 |
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| 書誌情報 |
藥學雜誌 = Journal of the Pharmaceutical Society of Japan 巻 133, 号 5, p. 501-506, 発行日 2013-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-6903 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00284903 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1248/yakushi.12-00278-3 | |||||
| 出版者 | ||||||
| 出版者 | The Pharmaceutical Society of Japan = 日本薬学会 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Schizophrenia is characterized by various behavioral abnormalities including cognitive dysfunction. Neonatal ventral hippocampus (NVH)-lesioned rats had been known as neurodevelopmental animal model similar to schizophrenia. Previous observations indicate that postpubertal NVH-lesioned rats exhibit impairments in prepulse inhibition (PPI), spontaneous locomotion, social interaction behavior and working memory. Here, we document the neurochemical basis of those defects in NVH-lesioned rats. Since Ca2+/calmodulin-dependent protein kinase II (CaMKII), which is NMDA receptor downstream kinase, is essential for memory and learning acquisition, we developed a protocol to monitor the spatial changes in CaMKII autophosphorylation using immunohistochemical imaging of whole brain slices with anti-autophosphorylated CaMKII antibody in order to address mechanisms underlying impaired cognitive function in NVH-lesioned rats. Immunohistochemical analyses using anti-autophosphorylated CaMKII antibody revealed that CaMKII autophosphorylation was significantly reduced in the medial prefrontal cortex (mPFC) of NVH-lesioned rats compared with control animals. This immunohistochemical technique is useful to investigate temporal and special changes in CaMKII activity in rodent brain and to evaluate drugs to improve the cognitive impairment. | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2013 by the PHARMACEUTICAL SOCIETY OF JAPAN | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.pharm.or.jp/ | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/browse/yakushi | |||||
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| 識別子タイプ | URI | |||||
| 関連識別子 | http://ci.nii.ac.jp/naid/130003361942 | |||||
