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Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: Possible association with malignancy
http://hdl.handle.net/2297/31979
http://hdl.handle.net/2297/3197939672d80-6072-410d-92ec-52ff7121ae3f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-FUJIMOTO-M-710.pdf (4.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: Possible association with malignancy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ichimura, Yuki
× Ichimura, Yuki× Matsushita, Takashi× Hamaguchi, Yasuhito× Kaji, Kenzo× Hasegawa, Minoru× Tanino, Yoshinori× Inokoshi, Yayoi× Kawai, Kazuhiro× Kanekura, Takuro× Habuchi, Maria× Igarashi, Atsuyuki× Sogame, Ryosuke× Hashimoto, Takashi× Koga, Tomohiro× Nishino, Ayako× Ishiguro, Naoko× Sugimoto, Naoki× Aoki, Rui× Ando, Noriko× Abe, Testsuya× Kanda, Takashi× Kuwana, Masataka× Takehara, Kazuhiko× Fujimoto, Manabu |
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| 書誌情報 |
Annals of the Rheumatic Diseases 巻 71, 号 5, p. 710-713, 発行日 2012-05-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0003-4967 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00533085 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1136/annrheumdis-2011-200697 | |||||
| 出版者 | ||||||
| 出版者 | BMJ Publishing Group | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: Myositis-specific autoantibodies (MSAs) are useful tools for identifying clinically homogeneous subsets and predicting prognosis of patients with idiopathic inflammatory myopathies (IIM) including polymyositis (PM) and dermatomyositis (DM). Recent studies have shown that anti-NXP2 antibody (Ab) is a major MSA in juvenile dermatomyositis (JDM). In this study the frequencies and clinical associations of anti-NXP2 Ab were evaluated in adult patients with IIM. Methods: Clinical data and serum samples were collected from 507 adult Japanese patients with IIM (445 with DM and 62 with PM). Eleven patients with JDM, 108 with systemic lupus erythematosus, 433 with systemic sclerosis and 124 with idiopathic pulmonary fibrosis were assessed as disease controls. Serum was examined for anti-NXP2 Ab by immunoprecipitation and western blotting using polyclonal anti-NXP2 Ab. Results: Seven patients (1.6%) with adult DM and one (1.6%) with adult PM were positive for anti-NXP2 Ab. Except for two patients with JDM, none of the disease controls were positive for this autoantibody. Among eight adult patients with IIM, three had internal malignancies within 3 years of diagnosis of IIM. Another patient with DM also had a metastatic cancer at the diagnosis. All of the carcinomas were at an advanced stage (stage IIIb-IV). Conclusions: While less common than in juvenile IIM, anti-NXP2 Ab was found in adult IIM. Anti-NXP2 Ab may be associated with adult IIM with malignancy. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
