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Management of postoperative hemorrhage associated with factor VIII inhibitor: report of a case
http://hdl.handle.net/2297/32465
http://hdl.handle.net/2297/324652202eae0-15d6-4af8-9a3f-e3d51263f5ab
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-ONISHI-I-1058.pdf (1.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Management of postoperative hemorrhage associated with factor VIII inhibitor: report of a case | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Onishi, Ichiro
× Onishi, Ichiro× Kayahara, Masato× Munemoto, Masayoshi× Sakai, Seisho× Makino, Isamu× Hayashi, Hironori× Nakagawara, Hisatoshi× Tajima, Hidehiro× Takamura, Hiroyuki× Kitagawa, Hirohisa× Tani, Takashi× Ohta, Tetsuo |
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| 書誌情報 |
Surgery Today 巻 43, 号 9, p. 1058-1061, 発行日 2013-09-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0941-1291 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10824685 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s00595-012-0286-6 | |||||
| 出版者 | ||||||
| 出版者 | Japan Surgical Society = 日本外科学会 / Springer | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This report presents a case that was successfully treated for acquired factor VIII inhibitor after extensive visceral surgery. A 71-year-old male who underwent surgery for bile duct cancer had active bleeding in the abdominal drainage tube on postoperative day (POD) 5, and prolonged activated partial thromboplastin time (aPTT) was detected (83.1 s) on POD 7. An extensive coagulation work-up revealed factor VIII deficiency (1 %), and a diagnosis of an acquired factor VIII deficiency was established when a factor VIII inhibitor of 8 Bethesda units was demonstrated. The patient was treated with activated prothrombin complex concentrate (aPCCs) and bloody discharge was stopped within 3 days. Inhibitor elimination was started using prednisolone on POD 20; rituximab, was administered on POD 74 and 81. Factor VIII inhibitor had disappeared by POD 124, and factor VIII (72 %) and aPTT recovered to 45.9 s. This case report demonstrated the efficacy of aPCCs and rituximab in the treatment of acquired hemophilia associated with visceral surgery. © 2012 Springer. | |||||
| 権利 | ||||||
| 権利情報 | © 2012 Springer | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
