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E6 and E7 variants of human papillomavirus-16 and -52 in Japan, the Philippines, and Vietnam
http://hdl.handle.net/2297/34675
http://hdl.handle.net/2297/346758665be91-c9c0-4e49-950a-d834ab4a06b2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-ISHIZAKI-A-1069.pdf (445.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | E6 and E7 variants of human papillomavirus-16 and -52 in Japan, the Philippines, and Vietnam | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ishizaki, Azumi
× Ishizaki, Azumi× Matsushita, Kaori× Hoang, Huyen Thi Thanh× Agdamag, Dorothy M.× Nguyen, Cuong Hung× Tran, Vuong Thi× Sasagawa, Toshiyuki× Saikawa, Kunikazu× Lihana, Raphael× Pham, Hung Viet× Bi, Xiuqiong× Ta, Van Thanh× Pham, Thuc Van× Ichimura, Hiroshi |
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| 書誌情報 |
Journal of Medical Virology 巻 85, 号 6, p. 1069-1076, 発行日 2013-06-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0146-6615 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00702400 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/jmv.23566 | |||||
| 出版者 | ||||||
| 出版者 | Wiley Periodicals | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Human papillomavirus (HPV) has several intragenotypic variants with different geographical and ethnic distributions. This study aimed to elucidate the distribution patterns of E6 and E7 (E6/E7) intragenotypic variants of HPV type 16 (HPV-16), which is most common worldwide, and HPV-52, which is common in Asian countries such as Japan, the Philippines, and Vietnam. In previous studies, genomic DNA samples extracted from cervical swabs were collected from female sex workers in these three countries and found to be positive for HPV-16 or HPV-52. Samples were amplified further for their E6/E7 genes using type-specific primers and analyzed genetically. Seventy-nine HPV-16 E6/E7 genes were analyzed successfully and grouped into three lineages: European (Prototype), European (Asian), and African-2. The prevalences of HPV-16 European (Prototype)/European (Asian) lineages were 19.4%/80.6% (n=31) in Japan, 75.0%/20.8% (n=24) in the Philippines, and 0%/95.8% (n=24) in Vietnam. The 109 HPV-52 E6/E7 genes analyzed successfully were grouped into four lineages, A-D; the prevalences of lineages A/B/C/D were, respectively, 5.1%/92.3%/0%/2.6% in Japan (n=39), 34.4%/62.5%/0%/3.1% in the Philippines (n=32), and 15.8%/73.7%/7.9%/2.6% in Vietnam (n=38). The distribution patterns of HPV-16 and HPV-52 lineages in these countries differed significantly (P<0.000001 and P=0.0048, respectively). There was no significant relationship between abnormal cervical cytology and either HPV-16 E6/E7 lineages or specific amino acid mutations, such as E6 D25E, E6 L83V, and E7 N29S. Analysis of HPV-16 and HPV-52 E6/E7 genes can be a useful molecular-epidemiological tool to distinguish geographical diffusion routes of these HPV types in Asia. © 2013 Wiley Periodicals, Inc. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
