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The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells
http://hdl.handle.net/2297/37479
http://hdl.handle.net/2297/37479fc5f3567-d1cd-4934-b8ed-cb80f85e2b14
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-KOIDE-H-752.pdf (4.0 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tada, Yuhki
× Tada, Yuhki× Yamaguchi, Yukari× Kinjo, Tomoaki× Song, Xiahong× Akagi, Tadayuki× Takamura, Hiroyuki× Ohta, Tetsuo× Yokota, Takashi× Koide, Hiroshi |
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| 書誌情報 |
Oncogene 巻 34, 号 6, p. 752-760, 発行日 2015-02-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0950-9232 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10687380 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/onc.2013.599 | |||||
| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Several common biological properties between cancer cells and embryonic stem (ES) cells suggest the possibility that some genes expressed in ES cells might have important roles in cancer cell growth. The transcription factor ZFP57 is expressed in self-renewing ES cells and its expression level decreases during ES cell differentiation. This study showed that ZFP57 is involved in the anchorage-independent growth of human fibrosarcoma HT1080 cells in soft agar. ZFP57 overexpression enhanced, whereas knockdown suppressed, HT1080 tumor formation in nude mice. Furthermore, ZFP57 regulates the expression of insulin-like growth factor 2 (IGF2), which has a critical role in ZFP57-induced anchorage-independent growth. ZFP57 also promotes anchorage-independent growth in ES cells and immortal fibroblasts. Finally, immunohistochemical analysis revealed that ZFP57 is overexpressed in human cancer clinical specimens. Taken together, these results suggest that the ES-specific transcription factor ZFP57 is a novel oncogene.Oncogene advance online publication, 27 January 2014; doi:10.1038/onc.2013.599. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
