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Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes
http://hdl.handle.net/2297/36897
http://hdl.handle.net/2297/36897c1fd6100-ebc2-4cfd-b9c6-1ebb790d24bf
名前 / ファイル | ライセンス | アクション |
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ME-PR-WADA-T-613.pdf (207.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Wada, Takashi
× Wada, Takashi× Haneda, Masakazu× Furuichi, Kengo× Babazono, Tetsuya× Yokoyama, Hiroki× Iseki, Kunitoshi× Araki, Shin-ichi× Ninomiya, Toshiharu× Hara, Shigeko× Suzuki, Yoshiki× Iwano, Masayuki× Kusano, Eiji× Moriya, Tatsumi× Satoh, Hiroaki× Nakamura, Hiroyuki× Shimizu, Miho× Toyama, Tadashi× Hara, Akinori× Makino, Hirofumi |
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書誌情報 |
Clinical and Experimental Nephrology 巻 18, 号 4, p. 613-620, 発行日 2014-08-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1342-1751 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11126935 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10157-013-0879-4 | |||||
出版者 | ||||||
出版者 | Japanese Society of Nephrology (JSN) 日本腎臓学会 / Springer Verlag (Germany) | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: The number of patients suffering from diabetic nephropathy resulting in end-stage kidney disease is increasing worldwide. In clinical settings, there are limited data regarding the impact of the urinary albumin-to-creatinine ratio (UACR) and reduced estimated glomerular filtration rate (eGFR) on renal and cardiovascular outcomes and all-cause mortality. Methods: We performed a historical cohort study of 4328 Japanese participants with type 2 diabetes from 10 centers. Risks for renal events (requirement for dialysis or transplantation, or half reduction in eGFR), cardiovascular events (cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke), and all-cause mortality were assessed according to UACR and eGFR levels. Results: During follow-up (median 7.0 years, interquartile range 3.0-8.0 years), 419 renal events, 605 cardiovascular events and 236 deaths occurred. The UACR levels increased the risk and the adjusted hazard ratios for these three events. In addition to the effects of UACR levels, eGFR stages significantly increased the adjusted hazard ratios for renal events and all-cause mortality, especially in patients with macroalbuminuria. Diabetic nephropathy score, based on the prognostic factors, well predicted incidence rates per 1000 patient/year for each event. Conclusions: Increased UACR levels were closely related to the increase in risks for renal, cardiovascular events and all-cause mortality in Japanese patients with type 2 diabetes, whereas the association between high levels of UACR and reduced eGFR was a strong predictor for renal events. © 2013 Japanese Society of Nephrology. | |||||
権利 | ||||||
権利情報 | © 2013 Japanese Society of Nephrology.| The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.jsn.or.jp/ |