| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-03 |
| タイトル |
|
|
タイトル |
Reciprocal changes in factor XIII and retinal transglutaminase expressions in the fish retina during optic nerve regeneration. |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00014066 |
|
ID登録タイプ |
JaLC |
| 著者 |
Sugitani, Kayo
Ogai, Kazuhiro
Koriyama, Yoshiki
Kato, Satoru
|
| 著者別表示 |
杉谷, 加代
大貝, 和裕
郡山, 恵樹
加藤, 聖
|
| 提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健研究域医学系 |
| 書誌情報 |
Advances in experimental medicine and biology
巻 801,
p. 759-764,
発行日 2014-01-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0065-2598 |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00512642 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/978-1-4614-3209-8_95 |
| 出版者 |
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出版者 |
Kluwer |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Unlike mammals, fish retinal ganglion cells have the capacity to repair their axons even after optic nerve transection. In the process of fish optic nerve regeneration, a large number of genes have been described as regeneration-associated molecules. Using molecular cloning techniques, we identified two types of cDNA clones belonging to the transglutaminase (TG) family which were upregulation genes; one is cellular factor XIII (cFXIII) and the other is a tissue type TG named retinal transglutaminase (TGR). cFXIII mRNA started to increase in the retinal ganglion cells at 1-2 days, peaked at 5-7 days, and returned to the control level by 20 days post optic nerve injury. In contrast, TGR mRNA started to increase at day 5-10, peaked at day 20, and then gradually decreased by day 40 after nerve injury. To elucidate the molecular involvement of these TGs in optic nerve regeneration, we studied the effects of recombinant TGR protein or overexpression of cFXIII using a retinal explant culture system. cFXIII effectively induced neurite outgrowth only from naïve (intact) retinas. In contrast, the TGR protein significantly enhanced neurite outgrowth only from primed retinas, in which the optic nerve had been crushed 5-7 days previously. These reciprocal expressions of cFXIII and TGR suggest that these two types of TGs are important for the neurite sprouting and axonal elongation processes, respectively, during optic nerve regeneration processes. |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
ME-PR-SUGITANI-K-759.pdf (178.4 kB)
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