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Differentiation of Donor-Derived Cells into Microglia after Umbilical Cord Blood Stem Cell Transplantation
http://hdl.handle.net/2297/43442
http://hdl.handle.net/2297/434421ba4e79a-b443-4d28-a4d5-5aae0c13b8e4
名前 / ファイル | ライセンス | アクション |
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ME-PR-TAKAHASHI-K-862.pdf (320.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Differentiation of Donor-Derived Cells into Microglia after Umbilical Cord Blood Stem Cell Transplantation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Takahashi, Kazuya
× Takahashi, Kazuya× Kakuda, Yumiko× Munemoto, Saori× Yamazaki, Hirohito× Nozaki, Ichiro× Yamada, Masahito |
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書誌情報 |
Journal of Neuropathology and Experimental Neurology 巻 74, 号 9, p. 862-866, 発行日 2015-09-29 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022-3069 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00703323 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1097/NEN.0000000000000234 | |||||
出版者 | ||||||
出版者 | American Association of Neuropathologists / Lippincott Williams and Wilkins | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Recent studies have indicated that microglia originate from immature progenitors in the yolk sac. After birth, microglial populations are maintained under normal conditions via self-renewal without the need to recruit monocyte-derived microglial precursors. Peripheral cell invasion of the brain parenchyma can only occur with disruption of the blood-brain barrier. Here, we report an autopsy case of an umbilical cord blood transplant recipient in whom cells derived from the donor blood differentiated into ramified microglia in the recipient brain parenchyma. Although the blood-brain barrier and glia limitans seemed to prevent invasion of these donor-derived cells, most of the invading donor-derived ramified cells were maintained in the cerebral cortex. This result suggests that invasion of donor-derived cells occurs through the pial membrane. Copyright © 2015 by the American Association of Neuropathologists, Inc. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |