WEKO3
アイテム
Dual Positive Regulation of Embryo Implantation by Endocrine and Immune Systems - Step-by-Step Maternal Recognition of the Developing Embryo
https://doi.org/10.24517/00014167
https://doi.org/10.24517/0001416762a9993b-3d5f-4b37-bb45-6add8f0ba3b4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-FUJIWARA-H-281.pdf (502.0 kB)
|
.png)
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||||||
| タイトル | ||||||||||
| タイトル | Dual Positive Regulation of Embryo Implantation by Endocrine and Immune Systems - Step-by-Step Maternal Recognition of the Developing Embryo | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.24517/00014167 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
Fujiwara, Hiroshi
× Fujiwara, Hiroshi× Araki, Yoshihiko× Imakawa, Kazuhiko× Saito, Shigeru× Daikoku, Takiko× Shigeta, Minoru× Kanzaki, Hideharu× Mori, Takahide |
|||||||||
| 著者別表示 |
藤原, 浩
× 藤原, 浩
× 大黒, 多希子
|
|||||||||
| 書誌情報 |
American Journal of Reproductive Immunology 巻 75, 号 3, p. 281-289, 発行日 2016-03-01 |
|||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1046-7408 | |||||||||
| NCID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA10729786 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1111/aji.12478 | |||||||||
| 出版者 | ||||||||||
| 出版者 | Blackwell Publishing | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | In humans, HCG secreted from the implanting embryo stimulates progesterone production of the corpus luteum to maintain embryo implantation. Along with this endocrine system, current evidence suggests that the maternal immune system positively contributes to the embryo implantation. In mice, immune cells that have been sensitized with seminal fluid and then the developing embryo induce endometrial differentiation and promote embryo implantation. After hatching, HCG activates regulatory T and B cells through LH/HCG receptors and then stimulates uterine NK cells and monocytes through sugar chain receptors, to promote and maintain pregnancy. In accordance with the above, the intrauterine administration of HCG-treated PBMC was demonstrated to improve implantation rates in women with repeated implantation failures. These findings suggest that the maternal immune system undergoes functional changes by recognizing the developing embryos in a stepwise manner even from a pre-fertilization stage and facilitates embryo implantation in cooperation with the endocrine system. © 2016 John Wiley & Sons A/S. | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Embargo Period 12 months | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
