| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-03 |
| タイトル |
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|
タイトル |
A possible role of neuroglobin in the retina after optic nerve injury: A comparative study of zebrafish and mouse retina |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00014261 |
|
ID登録タイプ |
JaLC |
| 著者 |
Sugitani, Kayo
Koriyama, Yoshiki
Ogai, Kazuhiro
Wakasugi, Keisuke
Kato, Satoru
|
| 著者別表示 |
杉谷, 加代
郡山, 恵樹
大貝, 和裕
加藤, 聖
|
| 書誌情報 |
Advances in Experimental Medicine and Biology
巻 854,
p. 671-675,
発行日 2016-10-01
|
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0065-2598 |
| NCID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00512642 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/978-3-319-17121-0_89 |
| 出版者 |
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出版者 |
Springer |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Neuroglobin (Ngb) is a new member of the family of heme proteins and is specifically expressed in neurons of the central and peripheral nervous systems in all vertebrates. In particular, the retina has a 100-fold higher concentration of Ngb than do other nervous tissues. The role of Ngb in the retina is yet to be clarified. Therefore, to understand the functional role of Ngb in the retina after optic nerve injury (ONI), we used two types of retina, from zebrafish and mice, which have permissible and non-permissible capacity for nerve regeneration after ONI, respectively. After ONI, the Ngb protein in zebrafish was upregulated in the amacrine cells within 3 days, whereas in the mouse retina, Ngb was downregulated in the retinal ganglion cells (RGCs) within 3 days. Zebrafish Ngb (z-Ngb) significantly enhanced neurite outgrowth in retinal explant culture. According to these results, we designed an overexpression experiment with the mouse Ngb (m-Ngb) gene in RGC-5 cells (retinal precursor cells). The excess of m-Ngb actually rescued RGC-5 cells under hypoxic conditions and significantly enhanced neurite outgrowth in cell culture. These data suggest that mammalian Ngb has positive neuroprotective and neuritogenic effects that induce nerve regeneration after ONI. © Springer International Publishing Switzerland 2016. |
| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
[Book Chapter] |
| 権利 |
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|
権利情報 |
The final publication is available at www.springerlink.com/10.1007%2F978-3-319-17121-0_89 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
ME-PR-SUGITANI-K-671.pdf (154.9 kB)
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