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Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 axis
http://hdl.handle.net/2297/47035
http://hdl.handle.net/2297/470355f88f1d7-1e4d-4959-bb92-7340243da339
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-IZUMI-K-9739.pdf (5.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 axis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Maolake, Aerken
× Maolake, Aerken× Izumi, Kouji× Shigehara, Kazuyoshi× Natsagdorj, Ariunbold× Iwamoto, Hiroaki× Kadomoto, Suguru× Takezawa, Yuta× Machioka, Kazuaki× Narimoto, Kazutaka× Namiki, Mikio× Lin, Wen-Jye× Wufuer, Guzailinuer× Mizokami, Atsushi |
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| 書誌情報 |
Oncotarget 巻 8, 号 6, p. 9739-9751, 発行日 2017-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1949-2553 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.18632/oncotarget.14185 | |||||
| 出版者 | ||||||
| 出版者 | Impact Journals LLC | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Previous studies have found that tumor-associated macrophages (TAMs) promote cancer progression. We previously reported that TAMs promote prostate cancer metastasis via activation of the CCL2-CCR2 axis. The CCR4 (receptor of CCL17 and CCL22) expression level in breast cancer was reported to be associated with lung metastasis. The aim of this study was to elucidate the role of CCR2 and CCR4 in prostate cancer progression. CCR2 and CCR4 were expressed in human prostate cancer cell lines and prostate cancer tissues. In vitro co-culture of prostate cancer cells and macrophages resulted in increased CCL2 and CCR2 levels in prostate cancer cells. The addition of CCL2 induced CCL22 and CCR4 production in prostate cancer cells. The migration and invasion of prostate cancer cells via enhanced phosphorylation of Akt were promoted by CCL17 and CCL22. CCR4 may be a potential candidate for molecular-targeted therapy. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
