WEKO3
インデックスリンク
アイテム
CETP deficiency and concerns in CETP inhibitor development
http://hdl.handle.net/2297/47079
http://hdl.handle.net/2297/47079b680c7d0-d973-480b-8e9c-c9c142186710
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-INAZU-A-2017.pdf (201.6 kB)
|
|
| Item type | 図書 / Book(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | CETP deficiency and concerns in CETP inhibitor development | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_2f33 | |||||
| 資源タイプ | book | |||||
| 著者 |
Inazu, Akihiro
× Inazu, Akihiro |
|||||
| 書誌情報 |
The HDL handbook 3rd Edition: Biological Functions and Clinical Implications 巻 Jan 7, 2016, 号 (Editors: Tsugikazu Komoda), p. 25p., 発行日 2017-02-22 |
|||||
| ISBN | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 9780128125137 | |||||
| 出版者 | ||||||
| 出版者 | Academic Press / Elsevier | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although some CETP-lowering SNPs in the CETP gene are variably associated with improved clinical outcomes in patients with coronary artery disease (CAD), three low molecular weight oral CETP inhibitors (torcetrapib, dalcetrapib, and evacetrapib) have not shown any clinical benefits despite remarkable increases in HDL-cholesterol levels ranging 31-138%. Potential causes for that failure are discussed in terms of off-target effects of some inhibitors, potential misleading interpretation of genetic epidemiological surveys in CETP gene, and inadequate alteration in HDL function induced by the inhibitors. Possible modalities of CETP inhibition such as antisense nucleotides and monoclonal antibodies are discussed. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | A part of the book | |||||
| 権利 | ||||||
| 権利情報 | © Academic Press 2017 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.elsevier.com/books/the-hdl-handbook/komoda/978-0-12-812513-7 | |||||
