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Diabetes mellitus is a major negative determinant of coronary plaque regression during statin therapy in patients with acute coronary syndrome: serial intravascular ultrasound observations from the Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome Trial (the JAPAN-ACS Trial).
https://doi.org/10.24517/00014368
https://doi.org/10.24517/00014368afd49579-b68d-4cdf-ad32-61199bfcb82f
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-YAMAGISHI-M-1165.pdf (647.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2018-06-15 | |||||||
| タイトル | ||||||||
| タイトル | Diabetes mellitus is a major negative determinant of coronary plaque regression during statin therapy in patients with acute coronary syndrome: serial intravascular ultrasound observations from the Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome Trial (the JAPAN-ACS Trial). | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00014368 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Hiro, Takafumi
× Hiro, Takafumi× Kimura, Takeshi× Morimoto, Takeshi× Miyauchi, Katsumi× Nakagawa, Yoshihisa× Yamagishi, Masakazu× Ozaki, Yukio× Kimura, Kazuo× Saito, Satoshi× Yamaguchi, Tetsu× Daida, Hiroyuki× Matsuzaki, Masunori× The JAPAN-ACS Investigators |
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| 著者別表示 |
山岸, 正和
× 山岸, 正和
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| 書誌情報 |
Circulation journal 巻 74, 号 6, p. 1165-1174, 発行日 2010-05-12 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1346-9843 | |||||||
| NCID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA11591968 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1253/circj.CJ-09-0766 | |||||||
| 出版者 | ||||||||
| 出版者 | Japanese Circulation Society = 日本循環器学会 | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Background: The Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome (JAPAN-ACS) trial has found that early aggressive statin therapy in patients with acute coronary syndrome (ACS) significantly reduces the plaque volume (PV) of non-culprit coronary lesions. The purpose of the present study was to evaluate clinical factors that have an impact on plaque regression using statin therapy. Methods and Results: Serial intravascular ultrasound observations over 8-12 months were performed in 252 ACS patients receiving pitavastatin or atorvastatin. Linear regression analysis identified the presence of diabetes mellitus (DM) and PV at baseline as inhibiting factors, and serum remnant-like particle-cholesterol level at baseline as a significant factor significantly affecting the degree of plaque regression. Significant correlation between % change of PV and low-density lipoprotein cholesterol (LDL-C) level was found in patients with DM (n=73, P<0.05, r=0.4), whereas there was no significant correlation between the 2 parameters in patients without DM (n=178). Conclusions: The regression of coronary plaque induced by statin therapy after ACS was weaker in diabetic patients than their counterparts. Moreover, vigorous reduction of the LDL-C levels might induce a greater degree of plaque regression in ACS patients with DM. (Circ J 2010; 74: 1165 - 1174) | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 出版者照会後に全文公開 | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © 2010 THE JAPANESE CIRCULATION SOCIETY | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.j-circ.or.jp/english/ | |||||||
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| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.jstage.jst.go.jp/browse/circj | |||||||
