| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-05-10 |
| タイトル |
|
|
タイトル |
Association of genetic variation of the adiponectin gene with body fat distribution and carotid atherosclerosis in Japanese obese subjects. |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00014440 |
|
ID登録タイプ |
JaLC |
| 著者 |
Katsuda, Yuko
Asano, Akimichi
Murase, Yuko
Chujo, Daisuke
Yagi, Kunimasa
Kobayashi, Junji
Mabuchi, Hiroshi
Yamagishi, Masakazu
|
| 著者別表示 |
八木, 邦公
小林, 淳二
馬渕, 宏
山岸, 正和
|
| 書誌情報 |
Journal of Atherosclerosis and Thrombosis
巻 14,
号 1,
p. 19-26,
発行日 2007-03-02
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1340-3478 |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11018976 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.5551/jat.14.19 |
| 出版者 |
|
|
出版者 |
Japan Atherosclerosis Society = 日本動脈硬化学会 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Aim: The aim of this study was to investigate the effect of SNP45 of the adiponectin gene on body fat distribution and carotid atherosclerosis in Japanese obese subjects. Methods: A total of 64 obese subjects were investigated. Genotypes of SNP45 were assayed by polymerase chain reaction-restriction fragment length polymorphism. Visceral fat area (VFA) and subcutaneous fat area (SFA) were measured using computed tomography. The progression of atherosclerosis was evaluated by plaque score (PS) of carotid artery using B-mode ultrasonography. Results: Men carrying the G allele of SNP45 showed higher VFA (172.8±50.8 vs. 147.1±58.7, p=0.005), lower SFA (209.9±101.8 vs. 273.4±142.2, p=0.007), higher VFA/SFA (V/S) ratio (1.00±0.46 vs. 0.60±0.26, p <0.001) and higher PS (9.5±3.7 vs. 6.8±4.2, p=0.012) than those with TT genotype. Multivariate analysis showed that SNP45 was an independent determinant of V/S ratio and PS in men. In subgroup analysis, PS tended to be associated with V/S ratio only in the carrier of 45G allele. Conclusion: These results suggest that the G allele could be a risk factor of metabolic syndrome and the development of atherosclerosis in Japanese obese subjects. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
出版者照会後に全文公開 |
| 権利 |
|
|
権利情報 |
Copyright © Japan Atherosclerosis Society 日本動脈硬化学会 (CC-BY NC SA) | 本論文の著作権は日本動脈硬化学会が保持しています |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.j-athero.org/en/index.html |
| 関連URI |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.jstage.jst.go.jp/browse/jat |
ME-PR-YAMAGISHI-M-19.pdf (292.4 kB)
.png)
