{"_buckets": {"deposit": "4156ba75-9498-42e5-ad4f-f2080b59b733"}, "_deposit": {"created_by": 3, "id": "14454", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "14454"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00014454", "sets": ["1134"]}, "author_link": ["342", "266", "75310", "389", "265", "513", "25047", "20207", "67114", "539", "333"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-01-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "518", "bibliographicPageStart": "512", "bibliographicVolumeNumber": "80", "bibliographic_titles": [{"bibliographic_title": "Circulation journal"}]}]}, "item_4_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "多田, 隼人"}], "nameIdentifiers": [{"nameIdentifier": "513", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90623653", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90623653"}, {"nameIdentifier": "90623653", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=90623653"}, {"nameIdentifier": "90623653", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090623653"}]}, {"creatorNames": [{"creatorName": "川尻, 剛照"}], "nameIdentifiers": [{"nameIdentifier": "333", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90345637", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90345637"}, {"nameIdentifier": "90345637", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=90345637"}, {"nameIdentifier": "90345637", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090345637"}]}, {"creatorNames": [{"creatorName": "寺本, 了太"}], "nameIdentifiers": [{"nameIdentifier": "75310", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90735169", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90735169"}]}, {"creatorNames": [{"creatorName": "野原, 淳"}], "nameIdentifiers": [{"nameIdentifier": "342", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50313648", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50313648"}, {"nameIdentifier": "50313648", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=50313648"}, {"nameIdentifier": "50313648", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000050313648"}]}, {"creatorNames": [{"creatorName": "稲津, 明広"}], "nameIdentifiers": [{"nameIdentifier": "539", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80293348", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80293348"}, {"nameIdentifier": "80293348", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=80293348"}, {"nameIdentifier": "80293348", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000080293348"}]}, {"creatorNames": [{"creatorName": "馬渕, 宏"}], "nameIdentifiers": [{"nameIdentifier": "389", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00019960", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00019960"}, {"nameIdentifier": "00019960", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000000019960"}]}, {"creatorNames": [{"creatorName": "山岸, 正和"}], "nameIdentifiers": [{"nameIdentifier": "265", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70393238", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70393238"}, {"nameIdentifier": "70393238", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=70393238"}, {"nameIdentifier": "70393238", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000070393238"}]}, {"creatorNames": [{"creatorName": "林, 研至"}], "nameIdentifiers": [{"nameIdentifier": "266", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00422642", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00422642"}, {"nameIdentifier": "00422642", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=00422642"}, {"nameIdentifier": "00422642", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000000422642"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background:It has been shown that serum lipoprotein(a) [Lp(a)] is elevated in familial hypercholesterolemia (FH) with mutation(s) of the LDL receptor (LDLR) gene. However, few data exist regarding Lp(a) levels in FH with gain-of-function mutations of the PCSK9 gene.Methods and Results:We evaluated 42 mutation-determined heterozygous FH patients with aPCSK9gain-of-function mutation (FH-PCSK9, mean age 52, mean LDL-C 235 mg/dl), 198 mutation-determined heterozygous FH patients with aLDLRmutation (FH-LDLR, mean age 44, mean LDL-C 217 mg/dl), and 4,015 controls (CONTROL, mean age 56, mean LDL-C 109 mg/dl). We assessed their Lp(a), total cholesterol, triglycerides, HDL-C, LDL-C, use of statins, presence of hypertension, diabetes, chronic kidney disease, smoking, body mass index (BMI) and coronary artery disease (CAD). Multiple regression analysis showed that HDL-C, use of statins, presence of hypertension, smoking, BMI, and Lp(a) were independently associated with the presence of CAD. Under these conditions, the serum levels of Lp(a) in patients with FH were significantly higher than those of the CONTROL group regardless of their causative genes, among the groups propensity score-matched (median Lp(a) 12.6 mg/dl [IQR:9.4–33.9], 21.1 mg/dl [IQR:11.7–34.9], and 5.0 mg/dl [IQR:2.7–8.1] in the FH-LDLR, FH-PCSK9, and CONTROL groups, respectively, P=0.002 for FH-LDLR vs. CONTROL, P=0.002 for FH-PCSK9 vs. CONTROL).Conclusions:These data demonstrate that serum Lp(a) is elevated in patients with FH caused by PCSK9 gain-of-function mutations to the same level as that in FH caused by LDLR mutations. (Circ J 2016; 80: 512–518)", "subitem_description_type": "Abstract"}]}, "item_4_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "出版者照会後に全文公開", "subitem_description_type": "Other"}]}, "item_4_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00014441", "subitem_identifier_reg_type": "JaLC"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Japanese Circulation Society = 日本循環器学会"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1253/circj.CJ-15-0999", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.j-circ.or.jp/english/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.jstage.jst.go.jp/browse/circj", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © 2015 THE JAPANESE CIRCULATION SOCIETY"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11591968", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1346-9843", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tada, Hayato"}], "nameIdentifiers": [{"nameIdentifier": "513", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90623653", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90623653"}, {"nameIdentifier": "90623653", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=90623653"}, {"nameIdentifier": "90623653", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090623653"}]}, {"creatorNames": [{"creatorName": "Kawashiri, Masa-aki"}], "nameIdentifiers": [{"nameIdentifier": "333", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90345637", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90345637"}, {"nameIdentifier": "90345637", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=90345637"}, {"nameIdentifier": "90345637", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090345637"}]}, {"creatorNames": [{"creatorName": "Yoshida, Taiji"}], "nameIdentifiers": [{"nameIdentifier": "67114", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Teramoto, Ryota"}], "nameIdentifiers": [{"nameIdentifier": "25047", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90735169", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090735169"}]}, {"creatorNames": [{"creatorName": "Nohara, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "342", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50313648", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50313648"}, {"nameIdentifier": "50313648", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=50313648"}, {"nameIdentifier": "50313648", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000050313648"}]}, {"creatorNames": [{"creatorName": "Konno, Tetsuo"}], "nameIdentifiers": [{"nameIdentifier": "20207", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50377389", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50377389"}, {"nameIdentifier": "50377389", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=50377389"}, {"nameIdentifier": "50377389", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000050377389"}]}, {"creatorNames": [{"creatorName": "Inazu, Akihiro"}], "nameIdentifiers": [{"nameIdentifier": "539", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80293348", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80293348"}, {"nameIdentifier": "80293348", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=80293348"}, {"nameIdentifier": "80293348", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000080293348"}]}, {"creatorNames": [{"creatorName": "Mabuchi, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "389", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00019960", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00019960"}, {"nameIdentifier": "00019960", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000000019960"}]}, {"creatorNames": [{"creatorName": "Yamagishi, Masakazu"}], "nameIdentifiers": [{"nameIdentifier": "265", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70393238", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70393238"}, {"nameIdentifier": "70393238", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=70393238"}, {"nameIdentifier": "70393238", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000070393238"}]}, {"creatorNames": [{"creatorName": "Hayashi, Kenshi"}], "nameIdentifiers": [{"nameIdentifier": "266", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00422642", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00422642"}, {"nameIdentifier": "00422642", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=00422642"}, {"nameIdentifier": "00422642", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000000422642"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-15"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-YAMAGISHI-M-512.pdf", "filesize": [{"value": "813.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 813500.0, "url": {"label": "ME-PR-YAMAGISHI-M-512.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/14454/files/ME-PR-YAMAGISHI-M-512.pdf"}, "version_id": "0ba1d8d9-f199-4e84-9237-fd6ce98f9b48"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Familial hypercholesterolemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lipoprotein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lipoprotein(a)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Low-density lipoprotein receptor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Proprotein convertase subtilisin/kexin type 9 (PCSK9)", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Lipoprotein(a) in Familial Hypercholesterolemia With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gain-of-Function Mutations.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Lipoprotein(a) in Familial Hypercholesterolemia With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gain-of-Function Mutations."}]}, "item_type_id": "4", "owner": "3", "path": ["1134"], "permalink_uri": "https://doi.org/10.24517/00014441", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-06-15"}, "publish_date": "2016-06-15", "publish_status": "0", "recid": "14454", "relation": {}, "relation_version_is_last": true, "title": ["Lipoprotein(a) in Familial Hypercholesterolemia With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gain-of-Function Mutations."], "weko_shared_id": 3}