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Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation
http://hdl.handle.net/2297/35645
http://hdl.handle.net/2297/356454bf9b189-7356-45be-a7d5-2c0a3dfc5c76
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-SAKURAI-T-14549.pdf (4.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Soya, Shingo
× Soya, Shingo× Shoji, Hirotaka× Hasegawa, Emi× Hondo, Mari× Miyakawa, Tsuyoshi× Yanagisawa, Masashi× Mieda, Michihiro× Sakurai, Takeshi |
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| 書誌情報 |
Journal of Neuroscience 巻 33, 号 36, p. 14549-14557, 発行日 2013-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0270-6474 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10620404 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1523/JNEUROSCI.1130-13.2013 | |||||
| 出版者 | ||||||
| 出版者 | Society for Neuroscience | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The noradrenergic (NA) projections arising from the locus ceruleus (LC) to the amygdala and bed nucleus of the stria terminalis have been implicated in the formation of emotional memory. Since NA neurons in the LC (LC-NA neurons) abundantly express orexin receptor-1 (OX1R) and receive prominent innervation by orexin-producing neurons, we hypothesized that an OX1R-mediated pathway is involved in the physiological fear learning process via regulation of LC-NA neurons. To evaluate this hypothesis, we examined the phenotype of Ox1r-/- mice in the classic cued and contextual fear-conditioning test. We found that Ox1r-/- mice showed impaired freezing responses in both cued and contextual fear-conditioning paradigms. In contrast, Ox2r-/- mice showed normal freezing behavior in the cued fear-conditioning test, while they exhibited shorter freezing time in the contextual fear-conditioning test. Double immunolabeling of Fos and tyrosine hydroxylase showed that double-positive LC-NA neurons after test sessions of both cued and contextual stimuli were significantly fewer in Ox1r-/- mice. AAV-mediated expression of OX1R in LC-NA neurons in Ox1r-/- mice restored the freezing behavior to the auditory cue to a comparable level to that in wild-type mice in the test session. Decreased freezing time during the contextual fear test was not affected by restoring OX1R expression in LC-NA neurons. These observations support the hypothesis that the orexin system modulates the formation and expression of fear memory via OX1R in multiple pathways. Especially, OX1R in LC-NA neurons plays an important role in cue-dependent fear memory formation and/or retrieval. © 2013 the authors. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
