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Various Molecular Species of Diacylglycerol Hydroperoxide Activate Human Neutrophils via PKC Activation
http://hdl.handle.net/2297/39190
http://hdl.handle.net/2297/39190682b4233-aa01-4996-9cb8-78d850a7e619
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-KAMBAYASHI-Y-68.pdf (343.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Various Molecular Species of Diacylglycerol Hydroperoxide Activate Human Neutrophils via PKC Activation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kambayashi, Yasuhiro
× Kambayashi, Yasuhiro× Takekoshi, Susumu× Tanino, Yutaka× Watanabe, Keiichi× Nakano, Minoru× Hitomi, Yoshiaki× Takigawa, Tomoko× Ogino, Keiki× Yamamoto, Yorihiro |
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| 書誌情報 |
Journal of Clinical Biochemistry and Nutrition 巻 41, 号 1, p. 68-75, 発行日 2007-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0912-0009 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10710201 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3164/jcbn.2007009 | |||||
| 出版者 | ||||||
| 出版者 | The Editorial Secretariat of JCBN = 日本酸化ストレス学会 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have proposed that diacylglycerol hydroperoxide-induced unregulated signal transduction causes oxidative stress-related diseases. In this study, we investigated which molecular species of diacylglycerol hydroperoxide activated human peripheral neutrophils. All diacylglycerol hydroperoxides, diacylglycerol hydroxides, and diacyglycerols tested in the present study induced superoxide production by neutrophils. The ability to activate neutrophils among molecular species containing the same fatty acid composition was as follows; diacylglycerol hydroperoxide>diacylglycerol hydroxide≥diacylglycerol. The diacylglycerol hydroperoxide composed of linoleate was a stronger activator for neutrophils than that composed of arachidonate. 1-Palmitoyl-2-linoleoylglycerol hydroperoxide (PLG-OOH) was the strongest stimulator for neutrophils. We reconfirmed that PLG-OOH activated protein kinase C (PKC) in neutrophils. PLG-OOH induced the phosphorylation of p47phox, a substrate of PKC and a cytosolic component of NADPH oxidase, in neutrophils, as did N-formyl-methionyl-leucyl-phenylalanine or 4β-phorbol-12β-myristate-13α-acetate. Moreover, the time course of p47phox phosphorylation was comparable to that of superoxide production. These results suggest that PLG-OOH activated intracellular protein kinase C. PLG-OOH, produced via an uncontrolled process, can act as a biological second messenger to cause inflammatory disease from oxidative stress. | |||||
| 権利 | ||||||
| 権利情報 | Copyright © The Editorial Secretariat of JCBN 日本酸化ストレス学会 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/browse/jcbn | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://sfrrj.umin.jp/JCBN.htm | |||||
