{"_buckets": {"deposit": "267a75a8-6869-4736-bb53-655b39851ec6"}, "_deposit": {"created_by": 3, "id": "14715", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "14715"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00014715", "sets": ["1134"]}, "author_link": ["26202", "26205", "26203", "26204", "26201", "26199", "88", "21891", "26200"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007-01-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "75", "bibliographicPageStart": "68", "bibliographicVolumeNumber": "41", "bibliographic_titles": [{"bibliographic_title": "Journal of Clinical Biochemistry and Nutrition"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We have proposed that diacylglycerol hydroperoxide-induced unregulated signal transduction causes oxidative stress-related diseases. In this study, we investigated which molecular species of diacylglycerol hydroperoxide activated human peripheral neutrophils. All diacylglycerol hydroperoxides, diacylglycerol hydroxides, and diacyglycerols tested in the present study induced superoxide production by neutrophils. The ability to activate neutrophils among molecular species containing the same fatty acid composition was as follows; diacylglycerol hydroperoxide\u003ediacylglycerol hydroxide≥diacylglycerol. The diacylglycerol hydroperoxide composed of linoleate was a stronger activator for neutrophils than that composed of arachidonate. 1-Palmitoyl-2-linoleoylglycerol hydroperoxide (PLG-OOH) was the strongest stimulator for neutrophils. We reconfirmed that PLG-OOH activated protein kinase C (PKC) in neutrophils. PLG-OOH induced the phosphorylation of p47phox, a substrate of PKC and a cytosolic component of NADPH oxidase, in neutrophils, as did N-formyl-methionyl-leucyl-phenylalanine or 4β-phorbol-12β-myristate-13α-acetate. Moreover, the time course of p47phox phosphorylation was comparable to that of superoxide production. These results suggest that PLG-OOH activated intracellular protein kinase C. PLG-OOH, produced via an uncontrolled process, can act as a biological second messenger to cause inflammatory disease from oxidative stress.", "subitem_description_type": "Abstract"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "The Editorial Secretariat of JCBN = 日本酸化ストレス学会"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3164/jcbn.2007009", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.jstage.jst.go.jp/browse/jcbn", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://sfrrj.umin.jp/JCBN.htm", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © The Editorial Secretariat of JCBN 日本酸化ストレス学会"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10710201", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0912-0009", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kambayashi, Yasuhiro"}], "nameIdentifiers": [{"nameIdentifier": "88", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20345630", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20345630"}, {"nameIdentifier": "20345630", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=20345630"}, {"nameIdentifier": "20345630", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000020345630"}]}, {"creatorNames": [{"creatorName": "Takekoshi, Susumu"}], "nameIdentifiers": [{"nameIdentifier": "26199", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanino, Yutaka"}], "nameIdentifiers": [{"nameIdentifier": "26200", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Keiichi"}], "nameIdentifiers": [{"nameIdentifier": "26201", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakano, Minoru"}], "nameIdentifiers": [{"nameIdentifier": "26202", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hitomi, Yoshiaki"}], "nameIdentifiers": [{"nameIdentifier": "21891", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70231545", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70231545"}, {"nameIdentifier": "70231545", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000070231545"}]}, {"creatorNames": [{"creatorName": "Takigawa, Tomoko"}], "nameIdentifiers": [{"nameIdentifier": "26203", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ogino, Keiki"}], "nameIdentifiers": [{"nameIdentifier": "26204", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Yorihiro"}], "nameIdentifiers": [{"nameIdentifier": "26205", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-03"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-KAMBAYASHI-Y-68.pdf", "filesize": [{"value": "343.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 343500.0, "url": {"label": "ME-PR-KAMBAYASHI-Y-68.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/14715/files/ME-PR-KAMBAYASHI-Y-68.pdf"}, "version_id": "0666ddef-cdf1-4c60-a917-47801a8910c4"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "1-palmitoyl-2-linoleoylglycerol hydroperoxide", "subitem_subject_scheme": "Other"}, {"subitem_subject": "neutrophil", "subitem_subject_scheme": "Other"}, {"subitem_subject": "oxidative stress", "subitem_subject_scheme": "Other"}, {"subitem_subject": "protein kinase C", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p47phox", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Various Molecular Species of Diacylglycerol Hydroperoxide Activate Human Neutrophils via PKC Activation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Various Molecular Species of Diacylglycerol Hydroperoxide Activate Human Neutrophils via PKC Activation"}]}, "item_type_id": "4", "owner": "3", "path": ["1134"], "permalink_uri": "http://hdl.handle.net/2297/39190", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-03"}, "publish_date": "2017-10-03", "publish_status": "0", "recid": "14715", "relation": {}, "relation_version_is_last": true, "title": ["Various Molecular Species of Diacylglycerol Hydroperoxide Activate Human Neutrophils via PKC Activation"], "weko_shared_id": -1}