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Activation of each promoter gives rise to a CYP19 mRNA species with a unique 5′-untranslated region. Inhibition of aromatase has been reported to downregulate lung tumor growth. The genetic basis for CYP19 gene expression and aromatase activity in lung cancer remains poorly understood. We analyzed tissues from 15 patients with non-small cell lung cancer (NSCLC) to evaluate CYP19 promoter usage and promoter-specific aromatase mRNA levels in NSCLC tumor tissues and adjacent non-malignant tissues. CYP19 promoter usage was determined by multiplex RT-PCR and aromatase mRNA levels were measured with real-time RT-PCR. In non-malignant tissues, aromatase mRNA was primarily derived from activation of CYP19 promoter I.4. Although promoter I.4 usage was also dominant in tumor tissues, I.4 activation was significantly lower compared with adjacent non-malignant tissues. Activity of promoters I.3, I.1 and I.7 was significantly higher in tumor tissues compared with non-malignant tissues. In 4 of 15 cases of non-small cell lung cancer, switching from CYP19 promoter I.4 to the alternative promoters II, I.1 or I.7 was observed. In 9 cases, there were significantly higher levels of aromatase mRNA in lung tumor tissues compared with adjacent non-malignant tissues. These findings suggest aberrant activation of alternative CYP19 promoters that may lead to upregulation of local aromatase expression in some cases of NSCLC. Further studies are needed to examine the impact of alternative CYP19 promoter usage on local estrogen levels and lung tumor growth. © 2011 Elsevier Ireland Ltd. 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  1. D. 医薬保健学域; 医学類・薬学類・医薬科学類・保健学類
  2. d 10. 学術雑誌掲載論文(医・保健)
  3. 1. 査読済論文(医学・保健)

Changes in aromatase (CYP19) gene promoter usage in non-small cell lung cancer

http://hdl.handle.net/2297/27075
http://hdl.handle.net/2297/27075
a1681052-e397-43f5-99f8-2dd7758601b6
名前 / ファイル ライセンス アクション
ME-PR-DEMURA-M-289.pdf ME-PR-DEMURA-M-289.pdf (178.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-10-03
タイトル
タイトル Changes in aromatase (CYP19) gene promoter usage in non-small cell lung cancer
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Demura, Masashi

× Demura, Masashi

WEKO 637
金沢大学研究者情報 00507080
研究者番号 00507080

Demura, Masashi

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Demura, Yoshiki

× Demura, Yoshiki

WEKO 2627