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Genetic diversity of HIV type 1 in Likasi, southeast of the Democratic Republic of Congo
http://hdl.handle.net/2297/26537
http://hdl.handle.net/2297/265373dc7e503-c023-4b74-8c32-ed3ef0e00bff
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-ICHIMURA-H-1352.pdf (86.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Genetic diversity of HIV type 1 in Likasi, southeast of the Democratic Republic of Congo | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kita, Kayoko
× Kita, Kayoko× Ndembi, Nicaise× Ekwalanga, Michel× Ido, Eiji× Kazadi, Rigobert× Bikandou, Blaise× Takehisa, Jun× Takemura, Taichiro× Kageyama, Seiji× Tanaka, Junji× Parra, Henri Joseph× Hayami, Masanori× Ichimura, Hiroshi |
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| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||
| 書誌情報 |
AIDS Research and Human Retroviruses 巻 200, 号 12, p. 1352-1357, 発行日 2004-12-01 |
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| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10689080 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1089/aid.2004.20.1352 | |||||
| 出版者 | ||||||
| 出版者 | Mary Ann Liebert | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To investigate the prevalence of subtypes A and C, and the existence of recombinants of both subtypes in the southeast of the Democratic Republic of Congo (DRC), blood samples were collected from 27 HIV-infected individuals in Likasi, located in an area bordering close to Zambia, and analyzed phylogenetically. Out of the 24 strains with a positive PCR profile for pol-IN and env-C2V3, 15 (62.5%) had a discordant subtype or CRF designation: one subtype A/G (pol/env), four A/U (unclassified), three G/A, one G/CRF01, three H/A, one J/C, one CRF02 (G)/A, and one U/A. Nine (37.5%) strains had a concordant subtype or CRF designation: five subtype A, two C, one D, and one CRF02/G. The remaining three samples negative for PCR with env-C2V3 primers used in this study were further analyzed with env-gp41 primers and revealed the presence of two profiles: two J/J (pol-IN/env-gp41) and one C/G. These data highlight the presence of a high proportion (16/27, 59.3%) of recombinant strains and a low prevalence (4.1 and 7.4%) of subtype C based on env-C2V3 and pol-IN analyses, respectively, in Likasi. In addition, this is the first report that CRF02_AG exists in DRC, though the epidemiological significance of the existence of CRF02_AG in DRC remains unknown. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
