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シトクロムP450と転写因子のmicroRNAによる発現制御
https://doi.org/10.24517/00014966
https://doi.org/10.24517/000149669fdff763-9290-42a1-a5ad-c2aa5ef29ffd
| 名前 / ファイル | ライセンス | アクション |
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PH-PR-NAKAJIMA-M-107.pdf (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2017-10-04 | |||||||
| タイトル | ||||||||
| タイトル | シトクロムP450と転写因子のmicroRNAによる発現制御 | |||||||
| タイトル | ||||||||
| タイトル | Role of MicroRNAs in the regulation of cytochrome P450s and transcriptional factors | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00014966 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
中嶋, 美紀
× 中嶋, 美紀 |
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| 著者別表示 |
Nakajima, Miki
× Nakajima, Miki
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学ナノ生命科学研究所 / 金沢大学医薬保健研究域薬学系 | |||||||
| 書誌情報 |
Yakugaku Zasshi 巻 132, 号 1, p. 107-116, 発行日 2012-01-01 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0031-6903 | |||||||
| NCID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AN00284903 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1248/yakushi.132.107 | |||||||
| 出版者 | ||||||||
| 出版者 | 日本薬学会 = The Pharmaceutical Society of Japan | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | MicroRNAs (miRNAs) are endogenous ~22-nucleotide non-coding RNAs that regulate gene expression through the translational repression or degradation of target mRNAs. The human genome contains over 1400 miRNAs and over 60% of human mRNAs are predicted to be targets of miRNAs. The miRNAs have roles in fine-tuning the expression of their target genes forming intricate networks. Research on miRNA is growing exponentially, and it is now clear that miRNAs can potentially regulate every aspect of cellular processes such as differentiation, proliferation and apoptosis as well as a large range of physiological processes such as development, immune response, metabolism, tumor formation, and disease development. The roles of miRNAs in the metabolism of xenobiotics and endobiotics have only recently been revealed. This review describes the current knowledge on the regulation of cytochrome P450s and transcriptional factors by miRNAs, and its physiological and clinical signifficance, which were disclosed in our studies. The miRNA expression is readily altered by chemicals, carcinogens, drugs, hormones, stress, or diseases, and the dysregulation of specific miRNAs might lead to changes in the drug metabolism potency or pharmacokinetics as well as pathophysiological changes. Utilizing miRNAs opens a new era in the fields of drug metabolism and pharmacokinetics as well as toxicology. © 2012 The Pharmaceutical Society of Japan. | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright (c) 2012 by the PHARMACEUTICAL SOCIETY OF JAPAN | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://japanlinkcenter.org/JST.JSTAGE/yakushi/132.107 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://yakushi.pharm.or.jp/ | |||||||
