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Studies on Metabolites of Macrophoma commelinae. III. : Isolation of New Metabolites and Biosynthesis of Macommelin Group
http://hdl.handle.net/2297/33671
http://hdl.handle.net/2297/33671a0a6f5af-8529-49a8-a45f-05a7d4f5b812
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PH-PR-SHIMIZU-S-1328.pdf (818.0 kB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-04 | |||||
| タイトル | ||||||
| タイトル | Studies on Metabolites of Macrophoma commelinae. III. : Isolation of New Metabolites and Biosynthesis of Macommelin Group | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Sakurai, Ikuo
× Sakurai, Ikuo× Shimizu, Sakae× Yamamoto, Yuzuru |
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| 書誌情報 |
Chemical & pharmaceutical bulletin 巻 36, 号 4, p. 1328-1335, 発行日 1988-04-25 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0009-2363 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00602100 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1248/cpb.36.1328 | |||||
| 出版者 | ||||||
| 出版者 | 日本薬学会 Pharmaceutical Society of Japan | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Three new metabolites, named macommelinal, macrophin and macrophic acid, were isolated from the culture broth of Macrophoma commelinae IFO 9570. Their structures were determined to be 2-(4-methoxy-6-methyl-2-oxo-2H-pyran-5-yl)ethanal, 3-methyl-2-butenoic acid (E)-[5-hydroxymethyl-4-methoxy-6-(2-methoxycarbonylethenyl)-2-oxo-2H-pyran-3-ly]methyl ester and 3-(4-methoxy-3,5-dimethyl-2-oxo-2H-pyran-6-yl)-2-propenoic acid, respectively. 4 Acetyl-3-methoxy-5-methylbenzoic acid, now named macrophomic acid, was also isolated from a large-scale culture.The biosynthesis of the macommelin group, novel 5-substituted 2-pyrone metabolites, has been investigated by feeding experiments with [1-^<13>C]-, [1,2-^<13>C_2]- and [1-^<13>C, 2-^2H_3]acetate and [2-^<13>C]malonate. It was concluded that all these metabolites originated from a single straight tetraketide chain. Furthermore, the biogenetic mutual relationships of these metabolites including potential intermediates were estabished through incorporation experiments with ^<14>C-labeled compounds. | |||||
| 権利 | ||||||
| 権利情報 | Copyright © The Pharmaceutical Society of Japan | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://ci.nii.ac.jp/naid/110003626918/ | |||||
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| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.pharm.or.jp/ | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/cpb1958/36/4/36_4_1328/_article | |||||
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| 識別子タイプ | URI | |||||
| 関連識別子 | https://japanlinkcenter.org/JST.Journalarchive/cpb1958/36.1328 | |||||
