WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "96519b08-35ee-4d08-b365-ae41c072ffff"}, "_deposit": {"created_by": 3, "id": "15077", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "15077"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00015077", "sets": ["1135"]}, "author_link": ["239", "27121", "27122"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1988-04-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "1335", "bibliographicPageStart": "1328", "bibliographicVolumeNumber": "36", "bibliographic_titles": [{"bibliographic_title": "Chemical \u0026 pharmaceutical bulletin"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Three new metabolites, named macommelinal, macrophin and macrophic acid, were isolated from the culture broth of Macrophoma commelinae IFO 9570. Their structures were determined to be 2-(4-methoxy-6-methyl-2-oxo-2H-pyran-5-yl)ethanal, 3-methyl-2-butenoic acid (E)-[5-hydroxymethyl-4-methoxy-6-(2-methoxycarbonylethenyl)-2-oxo-2H-pyran-3-ly]methyl ester and 3-(4-methoxy-3,5-dimethyl-2-oxo-2H-pyran-6-yl)-2-propenoic acid, respectively. 4 Acetyl-3-methoxy-5-methylbenzoic acid, now named macrophomic acid, was also isolated from a large-scale culture.The biosynthesis of the macommelin group, novel 5-substituted 2-pyrone metabolites, has been investigated by feeding experiments with [1-^\u003c13\u003eC]-, [1,2-^\u003c13\u003eC_2]- and [1-^\u003c13\u003eC, 2-^2H_3]acetate and [2-^\u003c13\u003eC]malonate. It was concluded that all these metabolites originated from a single straight tetraketide chain. Furthermore, the biogenetic mutual relationships of these metabolites including potential intermediates were estabished through incorporation experiments with ^\u003c14\u003eC-labeled compounds.", "subitem_description_type": "Abstract"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本薬学会 Pharmaceutical Society of Japan"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1248/cpb.36.1328", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://ci.nii.ac.jp/naid/110003626918/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.pharm.or.jp/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.jstage.jst.go.jp/article/cpb1958/36/4/36_4_1328/_article", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://japanlinkcenter.org/JST.Journalarchive/cpb1958/36.1328", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © The Pharmaceutical Society of Japan"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00602100", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0009-2363", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sakurai, Ikuo"}], "nameIdentifiers": [{"nameIdentifier": "27121", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimizu, Sakae"}], "nameIdentifiers": [{"nameIdentifier": "239", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "10110545", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=10110545"}, {"nameIdentifier": "10110545", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000010110545"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Yuzuru"}], "nameIdentifiers": [{"nameIdentifier": "27122", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PH-PR-SHIMIZU-S-1328.pdf", "filesize": [{"value": "818.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 818000.0, "url": {"label": "PH-PR-SHIMIZU-S-1328.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/15077/files/PH-PR-SHIMIZU-S-1328.pdf"}, "version_id": "1f800332-9e6b-4b5f-93f8-481b1ca3bf8b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Macrophoma commelinae IFO 9570", "subitem_subject_scheme": "Other"}, {"subitem_subject": "fung", "subitem_subject_scheme": "Other"}, {"subitem_subject": "metabolic product", "subitem_subject_scheme": "Other"}, {"subitem_subject": "macommelinal", "subitem_subject_scheme": "Other"}, {"subitem_subject": "macrophin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "macrophic acid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "macrophomic acid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "biosynthesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "macommelin group", "subitem_subject_scheme": "Other"}, {"subitem_subject": "2-pyrone", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Studies on Metabolites of Macrophoma commelinae. III. : Isolation of New Metabolites and Biosynthesis of Macommelin Group", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Studies on Metabolites of Macrophoma commelinae. III. : Isolation of New Metabolites and Biosynthesis of Macommelin Group"}]}, "item_type_id": "4", "owner": "3", "path": ["1135"], "permalink_uri": "http://hdl.handle.net/2297/33671", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-04"}, "publish_date": "2017-10-04", "publish_status": "0", "recid": "15077", "relation": {}, "relation_version_is_last": true, "title": ["Studies on Metabolites of Macrophoma commelinae. III. : Isolation of New Metabolites and Biosynthesis of Macommelin Group"], "weko_shared_id": -1}
Studies on Metabolites of Macrophoma commelinae. III. : Isolation of New Metabolites and Biosynthesis of Macommelin Group
http://hdl.handle.net/2297/33671
http://hdl.handle.net/2297/33671a0a6f5af-8529-49a8-a45f-05a7d4f5b812
名前 / ファイル | ライセンス | アクション |
---|---|---|
PH-PR-SHIMIZU-S-1328.pdf (818.0 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-04 | |||||
タイトル | ||||||
タイトル | Studies on Metabolites of Macrophoma commelinae. III. : Isolation of New Metabolites and Biosynthesis of Macommelin Group | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sakurai, Ikuo
× Sakurai, Ikuo× Shimizu, Sakae× Yamamoto, Yuzuru |
|||||
書誌情報 |
Chemical & pharmaceutical bulletin 巻 36, 号 4, p. 1328-1335, 発行日 1988-04-25 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0009-2363 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00602100 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/cpb.36.1328 | |||||
出版者 | ||||||
出版者 | 日本薬学会 Pharmaceutical Society of Japan | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Three new metabolites, named macommelinal, macrophin and macrophic acid, were isolated from the culture broth of Macrophoma commelinae IFO 9570. Their structures were determined to be 2-(4-methoxy-6-methyl-2-oxo-2H-pyran-5-yl)ethanal, 3-methyl-2-butenoic acid (E)-[5-hydroxymethyl-4-methoxy-6-(2-methoxycarbonylethenyl)-2-oxo-2H-pyran-3-ly]methyl ester and 3-(4-methoxy-3,5-dimethyl-2-oxo-2H-pyran-6-yl)-2-propenoic acid, respectively. 4 Acetyl-3-methoxy-5-methylbenzoic acid, now named macrophomic acid, was also isolated from a large-scale culture.The biosynthesis of the macommelin group, novel 5-substituted 2-pyrone metabolites, has been investigated by feeding experiments with [1-^<13>C]-, [1,2-^<13>C_2]- and [1-^<13>C, 2-^2H_3]acetate and [2-^<13>C]malonate. It was concluded that all these metabolites originated from a single straight tetraketide chain. Furthermore, the biogenetic mutual relationships of these metabolites including potential intermediates were estabished through incorporation experiments with ^<14>C-labeled compounds. | |||||
権利 | ||||||
権利情報 | Copyright © The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://ci.nii.ac.jp/naid/110003626918/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.pharm.or.jp/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/article/cpb1958/36/4/36_4_1328/_article | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://japanlinkcenter.org/JST.Journalarchive/cpb1958/36.1328 |