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Immunohistochemical analysis of CYP2A13 in various types of human lung cancers
https://doi.org/10.24517/00015106
https://doi.org/10.24517/000151062834ff37-3d4a-4a83-9ce1-603b7ffd5aa6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PH-PR-NAKAJIMA-M-1024.pdf (412.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2017-10-04 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Immunohistochemical analysis of CYP2A13 in various types of human lung cancers | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| ID登録 | ||||||||||||||||||
| ID登録 | 10.24517/00015106 | |||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||
| 著者 |
Fukami, Tatsuki
× Fukami, Tatsuki× Nakajima, Miki× Matsumoto, Isao× Zen, Yoh× Oda, Makoto× Yokoi, Tsuyoshi |
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| 著者別表示 |
深見, 達基
× 深見, 達基
× 中嶋, 美紀
× 松本, 勲
× 全, 陽
× 小田, 誠
× 横井, 毅
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| 提供者所属 | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | 金沢大学ナノ生命科学研究所 / 金沢大学医薬保健研究域薬学系 | |||||||||||||||||
| 書誌情報 |
Cancer Science 巻 101, 号 4, p. 1024-1028, 発行日 2010-04-01 |
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| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 1347-9032 | |||||||||||||||||
| NCID | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA11808050 | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | 10.1111/j.1349-7006.2009.01482.x | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Japanese Cancer Association / Blackwell Publishing Ltd | |||||||||||||||||
| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Human CYP2A13, which is expressed in the respiratory tract, is the most efficient enzyme for the metabolic activation of tobacco-specific nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). The relevance of CYP2A13 in carcinogenicity and toxicity in the respiratory tract has been suggested, but the expression of CYP2A13 protein in lung cancer tissues remains to be determined. We first prepared a mouse monoclonal antibody against human CYP2A13. The antibody showed no cross reactivity with the other CYP isoforms including CYP2A6. Using the specific antibody, we performed immunohistochemical analysis for human lung carcinomas. In adenocarcinomas (n=15), all specimens were positive for the staining and five samples showed strong staining. In squamous cell carcinomas (n=15) and large cell carcinomas (n=15), each 14 samples were positive for the staining and two and three samples showed strong staining, respectively. In small cell carcinoma samples (n=15), eight samples were negative for the staining and five samples showed weak or moderate staining. In conclusion, we first found that the expression of CYP2A13 was markedly increased in non-small cell lung carcinomas. The high expression might be associated with the tumor development and progression in non-small cell lung carcinomas. © 2010 Japanese Cancer Association. | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 権利情報 | © Japanese Cancer Association 日本癌学会 | |||||||||||||||||
| 著者版フラグ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| 関連URI | ||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||
| 関連識別子 | http://www.jca.gr.jp/ | |||||||||||||||||
