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Relationship between Neurological Symptoms and Concentrations of Clioquinol in Serum and Nervous Systems of Beagle Dogs
http://hdl.handle.net/2297/44903
http://hdl.handle.net/2297/449030d8cc88f-a11b-40ad-9311-4714d1e77b28
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PH-PR-HAYAKAWA-K-2013.pdf (675.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-04 | |||||
| タイトル | ||||||
| タイトル | Relationship between Neurological Symptoms and Concentrations of Clioquinol in Serum and Nervous Systems of Beagle Dogs | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Hayakawa, Kazuichi
× Hayakawa, Kazuichi× Imanari, Toshio× Tamura, Zenzo× Kuroda, Shigetoshi× Ikeda, Hisao× Tateishi, Jun |
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| 書誌情報 |
Chemical and Pharmaceutical Bulletin 巻 25, 号 8, p. 2013-2018, 発行日 1977-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0009-2363 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00602100 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1248/cpb.25.2013 | |||||
| 出版者 | ||||||
| 出版者 | 日本薬学会 = The Pharmaceutical Society of Japan | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Beagle dogs were orally administered with a fixed dose of clioquinol, 300 mg/kg/day, in gelatin capsules every day. Other beagle dogs were orally administered with powder clioquinol, 300 mg/kg/day after increasing dose, in milk twice a day. All beagle dogs administered with clioquinol developed weakness of the hind-limbs and hip swaying in several ten days. Individual differences and daily variations in serum levels of clioquinol, its sulfate and its glucuronide were large. Clioquinol was detected at higher concentrations not only in central nervous system but also in peripheral nervous system, and was retained for a long time. | |||||
| 権利 | ||||||
| 権利情報 | Copyright © The Pharmaceutical Society of Japan | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.pharm.or.jp/ | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/browse/cpb/-char/ja/ | |||||
