| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-04 |
| タイトル |
|
|
タイトル |
Anti-inflammatory effects of lipoic acid through inhibition of GSK-3β in lipopolysaccharide-induced BV-2 microglial cells |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00015216 |
|
ID登録タイプ |
JaLC |
| 著者 |
Koriyama, Yoshiki
Nakayama, Yuya
Matsugo, Seiichi
Sugitani, Kayo
Ogai, Kazuhiro
Takadera, Tsuneo
Kato, Satoru
|
| 著者別表示 |
郡山, 恵樹
松郷, 誠一
杉谷, 加代
大貝, 和裕
高寺, 恒雄
加藤, 聖
|
| 書誌情報 |
Neuroscience Research
巻 77,
号 1-2,
p. 87-96,
発行日 2013-09-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0168-0102 |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10641652 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.neures.2013.07.001 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Activated microglial cells play an important role in immune and inflammatory responses in CNS and play a role in neurodegenerative diseases. We examined the effects of lipoic acid (LA) on inflammatory responses of BV-2 microglial cells activated by lipopolysaccharide (LPS), and explored the underlying mechanisms of action of LA. BV-2 cells treated with LPS showed an up-regulation of mRNA of the pro-inflammatory molecules, inducible nitric oxide synthase (iNOS). LA suppressed the expression of iNOS and furthermore, LPS-induced production of nitrite. Moreover, LA suppressed the nuclear translocation of RelA, a component of nuclear factor-kappa B (NF-κB) that contains transcriptional activator domain for LPS. The mechanisms of LA-mediated anti-inflammatory effects on microglia remain unknown, and we suggested an involvement of Akt/glycogen synthase kinase-3β (GSK-3β) phosphorylation. The results showed that inhibitor of phosphatidylinositol 3-kinase prevented LA-mediated suppression of LPS induction of RelA and expression of iNOS. Furthermore, these inflammatory actions were prevented by GSK-3β inhibitors. These data demonstrate a role for LA as a chemical modulator of inflammatory responses by microglia, and thus may be a therapeutic strategy for treating neurodegenerative diseases with an inflammatory component. © 2013 Elsevier Ireland Ltd and the Japan Neuroscience Society. |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連URI |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.elsevier.com/locate/issn/01680102 |
ME-PR-KORIYAMA-Y-87.pdf (732.7 kB)
.png)
