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Anti-inflammatory effects of lipoic acid through inhibition of GSK-3β in lipopolysaccharide-induced BV-2 microglial cells
https://doi.org/10.24517/00015216
https://doi.org/10.24517/0001521616a4f7ad-d2ba-4a44-ad6a-cdd85bb047f1
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-KORIYAMA-Y-87.pdf (732.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2017-10-04 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Anti-inflammatory effects of lipoic acid through inhibition of GSK-3β in lipopolysaccharide-induced BV-2 microglial cells | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| ID登録 | ||||||||||||||||||
| ID登録 | 10.24517/00015216 | |||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||
| 著者 |
Koriyama, Yoshiki
× Koriyama, Yoshiki× Nakayama, Yuya× Matsugo, Seiichi× Sugitani, Kayo× Ogai, Kazuhiro× Takadera, Tsuneo× Kato, Satoru |
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| 著者別表示 |
郡山, 恵樹
× 郡山, 恵樹
× 松郷, 誠一
× 杉谷, 加代
× 大貝, 和裕
× 高寺, 恒雄
× 加藤, 聖
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| 書誌情報 |
Neuroscience Research 巻 77, 号 1-2, p. 87-96, 発行日 2013-09-01 |
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| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 0168-0102 | |||||||||||||||||
| NCID | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA10641652 | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | 10.1016/j.neures.2013.07.001 | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||||
| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Activated microglial cells play an important role in immune and inflammatory responses in CNS and play a role in neurodegenerative diseases. We examined the effects of lipoic acid (LA) on inflammatory responses of BV-2 microglial cells activated by lipopolysaccharide (LPS), and explored the underlying mechanisms of action of LA. BV-2 cells treated with LPS showed an up-regulation of mRNA of the pro-inflammatory molecules, inducible nitric oxide synthase (iNOS). LA suppressed the expression of iNOS and furthermore, LPS-induced production of nitrite. Moreover, LA suppressed the nuclear translocation of RelA, a component of nuclear factor-kappa B (NF-κB) that contains transcriptional activator domain for LPS. The mechanisms of LA-mediated anti-inflammatory effects on microglia remain unknown, and we suggested an involvement of Akt/glycogen synthase kinase-3β (GSK-3β) phosphorylation. The results showed that inhibitor of phosphatidylinositol 3-kinase prevented LA-mediated suppression of LPS induction of RelA and expression of iNOS. Furthermore, these inflammatory actions were prevented by GSK-3β inhibitors. These data demonstrate a role for LA as a chemical modulator of inflammatory responses by microglia, and thus may be a therapeutic strategy for treating neurodegenerative diseases with an inflammatory component. © 2013 Elsevier Ireland Ltd and the Japan Neuroscience Society. | |||||||||||||||||
| 著者版フラグ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
| 関連URI | ||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||
| 関連識別子 | http://www.elsevier.com/locate/issn/01680102 | |||||||||||||||||
