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MicroRNAs from biology to future pharmacotherapy: Regulation of cytochrome P450s and nuclear receptors
https://doi.org/10.24517/00015232
https://doi.org/10.24517/00015232e47cfb79-c207-4fe3-b6ff-0deb8a4d8b75
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PH-PR-NAKAJIMA-M-330.pdf (222.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2017-10-04 | |||||||||
| タイトル | ||||||||||
| タイトル | MicroRNAs from biology to future pharmacotherapy: Regulation of cytochrome P450s and nuclear receptors | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.24517/00015232 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
Nakajima, Miki
× Nakajima, Miki× Yokoi, Tsuyoshi |
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| 著者別表示 |
中嶋, 美紀
× 中嶋, 美紀
× 横井, 毅
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| 提供者所属 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 金沢大学ナノ生命科学研究所 / 金沢大学医薬保健研究域薬学系 | |||||||||
| 書誌情報 |
Pharmacology and Therapeutics 巻 131, 号 3, p. 330-337, 発行日 2011-09-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0163-7258 | |||||||||
| NCID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00361944 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1016/j.pharmthera.2011.04.009 | |||||||||
| 出版者 | ||||||||||
| 出版者 | Elsevier | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | MicroRNAs (miRNAs) are a family of short, non-coding RNAs whose final product is a 22-nucleotide functional RNA molecule. They regulate the expression of target genes by binding to complementary regions of transcripts to repress their translation or promote mRNA degradation. Since miRNAs regulate every aspect of cellular function, their dysregulation is associated with a variety of diseases including cancer, diabetes, and cardiovascular diseases. Therefore, miRNAs are now considered new therapeutic targets. However, the roles of miRNAs in the metabolism of xenobiotics and endobiotics have only recently been revealed. This review describes the current knowledge on the regulation of cytochrome P450s and nuclear receptors by miRNAs, the physiological and clinical significance. The miRNA expression is readily altered by chemicals, carcinogens, drugs, hormones, stress, or diseases, and the dysregulation of specific miRNAs might lead to changes in the drug metabolism potency or pharmacokinetics as well as pathophysiological changes. In the field of pharmacogenomics, the evaluation of miRNA-related polymorphisms would provide useful information for personalized medicine. Utilizing miRNAs opens a new era in the fields of drug metabolism and pharmacokinetics as well as toxicology. © 2011 Elsevier Inc. All rights reserved. | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://www.elsevier.com/locate/issn/01637258 | |||||||||
