| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-04 |
| タイトル |
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|
タイトル |
A randomized, quadruple crossover single-blind study on immediate action of chewed and unchewed low-dose acetylsalicylic acid tablets in healthy volunteers |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
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|
ID登録 |
10.24517/00015234 |
|
ID登録タイプ |
JaLC |
| 著者 |
Sai, Yoshimichi
Kusaka, Akiyo
Imanishi, Kaori
Matsumoto, Manami
Takahashi, Rie
Sugimoto, Natsumi
Sugama, Junko
Anada, Takako
Asakura, Hidesaku
Miyamoto, KenIchi
|
| 著者別表示 |
崔, 吉道
須釜, 淳子
朝倉, 英策
宮本, 謙一
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| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学附属病院薬剤部 |
| 書誌情報 |
Journal of Pharmaceutical Sciences
巻 100,
号 9,
p. 3884-3891,
発行日 2011-09-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0022-3549 |
| NCID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00704450 |
| DOI |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1002/jps.22602 |
| 出版者 |
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出版者 |
Wiley-Blackwell |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
In the initial treatment of acute myocardial infarction, it is important to administer oral low-dose acetylsalicylic acid (ASA) within 10 min of arrival at the hospital. However, ASA is supplied as an enteric-coated tablet or buffered tablet to prevent gastric irritation. Although current guidelines recommended that patients should chew their initial dose of ASA, there is little evidence as to whether this is efficacious. Therefore, we aimed to make a direct comparison of the pharmacokinetics and pharmacodynamics of ASA after ingestion of intact and chewed nonenteric-coated buffered ASA tablet (NBA) and enteric-coated ASA tablet (ECA) in a quadruple crossover study in healthy volunteers. Chewing ECA accelerated tmax of ASA absorption, which became equivalent to that after ingestion of intact or chewed NBA. A significant decrease in serum thromboxane B2 was observed 20 min after ingestion of chewed ECA, or intact or chewed NBA, and inhibition of platelet aggregation was also observed within 20 min. Thus, chewing of the ECA appears to result in a similar timing of ASA action to that in the case of chewed or unchewed NBA. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci Copyright © 2011 Wiley-Liss, Inc. |
| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
発行後1年より全文公開. |
| 著者版フラグ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
PH-PR-SAI-Y-3884.pdf (172.5 kB)
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