| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-04 |
| タイトル |
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|
タイトル |
Evaluation of radioiodinated vesamicol analogs for sigma receptor imaging in tumor and radionuclide receptor therapy |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
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|
ID登録 |
10.24517/00015278 |
|
ID登録タイプ |
JaLC |
| 著者 |
Ogawa, Kazuma
Shiba, Kazuhiro
Akhter, Nasima
Yoshimoto, Mitsuyoshi
Washiyama, Kohshin
Kinuya, Seigo
Kawai, Keiichi
Mori, Hirofumi
|
| 著者別表示 |
小川, 数馬
柴, 和弘
吉本, 光喜
鷲山, 幸信
絹谷, 清剛
川井, 恵一
|
| 提供者所属 |
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|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学新学術創成研究機構 / 金沢大学医薬保健研究域薬学系 |
| 書誌情報 |
Cancer Science
巻 100,
号 11,
p. 2188-2192,
発行日 2009-11-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1347-9032 |
| NCID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11808050 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1111/j.1349-7006.2009.01279.x |
| 出版者 |
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出版者 |
Japanese Cancer Association = 日本癌学会 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
It has been reported that sigma receptors are highly expressed in a variety of human tumors. In this study, we selected (+)-2-[4-(4-iodophenyl)piperidino] cyclohexanol [(+)-pIV] as a sigma receptor ligand and evaluated the potential of radioiodinated (+)-pIV for tumor imaging and therapy. (+)-[125/131I]pIV was prepared by an iododestannylation reaction under no-carrier-added conditions with radiochemical purity over 99% after HPLC purification. Biodistribution experiments were performed by the intravenous injection of (+)-[125I]pIV into mice bearing human prostate tumors (DU-145). Blocking studies were performed by intravenous injection of (+)-[125I]pIV mixed with an excess amount of unlabeled sigma ligand into DU-145 tumor-bearing mice. For therapeutic study, (+)-[131I]pIV was injected at a dose of 7.4 MBq followed by measurement of the tumor size. In biodistribution experiments, (+)-[125I]pIV showed high uptake and long residence in the tumor. High tumor to blood and muscle ratios were achieved because the radioactivity levels of blood and muscle were low. However, the accumulations of radioactivity in non-target tissues, such as liver and kidney, were high. The radioactivity in the non-target tissues slowly decreased over time. Co-injection of (+)-[125I]pIV with an excess amount of unlabeled sigma ligand resulted in a significant decrease in the tumor/blood ratio, indicating sigma receptor-mediated tumor uptake. In therapeutic study, tumor growth in mice treated with (+)-[131I]pIV was significantly inhibited compared to that of an untreated group. These results indicate that radioiodinated (+)-pIV has a high potential for sigma receptor imaging in tumor and radionuclide receptor therapy. (Cancer Sci 2009). © 2009 Japanese Cancer Association. |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
ME-PR-OGAWA-K-2188.pdf (231.6 kB)
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