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制がん性白金錯体シスプラチンのイオン交換体への保持挙動
http://hdl.handle.net/2297/25013
http://hdl.handle.net/2297/25013f07fc6be-9c36-42ee-8845-a88a2e90ffee
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PH-PR-KIZU-R-371.pdf (305.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-04 | |||||
| タイトル | ||||||
| タイトル | 制がん性白金錯体シスプラチンのイオン交換体への保持挙動 | |||||
| タイトル | ||||||
| タイトル | Retention behavior of an antitumor platinum complex Cisplatin on ion exchangers | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
木津, 良一
× 木津, 良一× 宮崎, 元一 |
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| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学医薬保健研究域薬学系 | |||||
| 書誌情報 |
分析化学 = Japan analyst 巻 39, 号 6, p. 371-374, 発行日 1990-06-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0525-1931 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00222633 | |||||
| 出版者 | ||||||
| 出版者 | The Japan Society for Analytical Chemistry = 日本分析化学会 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The novel aspects of Cisplatin, a patent antitumor platinum complex, on HPLC with ion exchange columns were studied. Although Cisplatin is an inorganic nonionic complex, it was retained on both anion and cation exchange columns, but not on reversed-phase columns. The capacity factor was larger on a column with higher ion exchange capacity ; a capacity factor of more than 30 was obtained in a system composed of an-ion exchange MCI GEL CA10S column and sodium dihydrogen phosphate eluent. However, the capacity factor measured on a column using the appropriate salt solution as the eluent was not affected by changing the concentration or pH of the eluent. The effect of UV absorptivity of an eluent on the peak height of Cisplatin was studied at various wavelengths in order to confirm the absence of an ion-exchange sorption mechanism in the eluent. No difference was observed between the relative peak height-detection wavelength profiles obtained with UV absorbing eluents and those obtained with UV-non absorbing eluents. These results indicated that Cisplatin might not be retained by ion exchange mechanism, but by other mechanisms such as ion-dipole interactions between Cisplatin and the functional groups of the stationary phases. | |||||
| 権利 | ||||||
| 権利情報 | Copyright (c) 1990 日本分析化学会 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.jsac.or.jp/index.html | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://ci.nii.ac.jp/naid/110002906141/en/ | |||||
