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Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1
http://hdl.handle.net/2297/23502
http://hdl.handle.net/2297/235022f0e658a-9547-4f27-821d-89c46c639da2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PH-PR-KATO-Y-832.pdf (6.9 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-04 | |||||
| タイトル | ||||||
| タイトル | Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kato, Yukio
× Kato, Yukio× Kubo, Yoshiyuki× Iwata, Daisuke× Kato, Sayaka× Sudo, Tomohisa× Sugiura, Tomoko× Kagaya, Takashi× Wakayama, Tomohiko× Hirayama, Akiyoshi× Sugimoto, Masahiro× Sugihara, Kazushi× Kaneko, Shuichi× Soga, Tomoyoshi× Asano, Masahide× Tomita, Masaru× Matsui, Toshiyuki× Wada, Morimasa× Tsuji, Akira |
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| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学医薬保健研究域薬学系 | |||||
| 書誌情報 |
Pharmaceutical Research 巻 27, 号 5, p. 832-840, 発行日 2010-05-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0724-8741 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10632083 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s11095-010-0076-z | |||||
| 出版者 | ||||||
| 出版者 | Springer Science+Business Media, LLC | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Solute carrier OCTN1 (SLC22A4) is an orphan transporter, the physiologically important substrate of which is still unidentified. The aim of the present study was to examine physiological roles of OCTN1. Methods: We first constructed octn1 gene knockout (octn1-/-) mice. Metabolome analysis was then performed to identify substrates in vivo. The possible association of the substrate identified with diseased conditions was further examined. Results: The metabolome analysis of blood and several organs indicated complete deficiency of a naturally occurring potent antioxidant ergothioneine in octn1-/- mice among 112 metabolites examined. Pharmacokinetic analyses after oral administration revealed the highest distribution to small intestines and extensive renal reabsorption of [3H]ergothioneine, both of which were much reduced in octn1-/- mice. The octn1-/- mice exhibited greater susceptibility to intestinal inflammation under the ischemia and reperfusion model. The blood ergothioneine concentration was also much reduced in Japanese patients with Crohn's disease, compared with healthy volunteers and patients with another inflammatory bowel disease, ulcerative colitis. Conclusions: These results indicate that OCTN1 plays a pivotal role for maintenance of systemic and intestinal exposure of ergothioneine, which could be important for protective effects against intestinal tissue injuries, providing a possible diagnostic tool to distinguish the inflammatory bowel diseases. © 2010 Springer Science+Business Media, LLC. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
