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非環式レチノイドは血小板由来増殖因子(PDGF)-C 過剰発現肝発癌モデルマウスの肝線維化・肝発癌を抑制する
http://hdl.handle.net/2297/35532
http://hdl.handle.net/2297/35532573333c3-4c05-4458-a223-a0df2b646df2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00044397-122-2-35-36.pdf (405.4 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2017-10-04 | |||||
| タイトル | ||||||
| タイトル | 非環式レチノイドは血小板由来増殖因子(PDGF)-C 過剰発現肝発癌モデルマウスの肝線維化・肝発癌を抑制する | |||||
| タイトル | ||||||
| タイトル | Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
岡田, 光
× 岡田, 光 |
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| 書誌情報 |
金沢大学十全医学会雑誌 = Journal of the Juzen Medical Society 巻 122, 号 2, p. 35-36, 発行日 2013-06-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0022-7226 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00044397 | |||||
| 出版者 | ||||||
| 出版者 | 金沢大学十全医学会 = The Juzen Medical Society Kanazawa University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hepatocellular carcinoma (HCC) often develops in association with liver cirrhosis, and its high recurrence rate leads to poor patient prognosis. Although recent evidence suggests that peretinoin, a member of the acyclic retinoid family, may be an effective chemopreventive drug for HCC, published data about its effects on hepatic mesenchymal cells, such as stellate cells and endothelial cells, remain limited. Using a mouse model in which platelet-derived growth factor (PDGF)-C is overexpressed (Pdgf-c Tg), resulting in hepatic fibrosis, steatosis, and eventually, HCC development, we show that peretinoin significantly represses the development of hepatic fibrosis and tumors. Peretinoin inhibited the signaling pathways of fibrogenesis, angiogenesis, and Wnt/β-catenin in Pdgfc transgenic mice. In vitro, peretinoin repressed the expression of PDGF receptors α/β in primary mouse hepatic stellate cells (HSC), hepatoma cells, fibroblasts, and endothelial cells. Peretinoin also inhibited PDGF-C-activated transformation of HSCs into myofibroblasts. Together, our findings show that PDGF signaling is a target of peretinoin in preventing the development of hepatic fibrosis and HCC. ©2012 AACR. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | [総説 / Reviews][博士課程優秀論文] 第11回 高安賞優秀論文賞受賞論文, Cancer Research 72 (17) , pp. 4459-4471(2012年9月掲載), Hikari Okada, Masao Honda, Jean S. Campbe, Yoshio Sakai, Taro Yamashita, Yuuki Takebuchi, Kazuhiro Hada, Takayoshi Shirasaki, Riuta Takabatake, Mikiko Nakamura,Hajime Sunagozaka, Takuji Tanaka, Nelson Fausto, and Shuichi Kaneko "Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development." http://dx.doi.org/10.1158/0008-5472.CAN-12-0028 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
