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受精鶏卵漿尿膜法を用いた悪性脳腫瘍に対する抗癌剤感受性試験
https://doi.org/10.24517/00017876
https://doi.org/10.24517/0001787652cb2974-68c9-42d1-baeb-a8d1d1f1da0f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN00044397-100-077.pdf (3.0 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-04 | |||||
| タイトル | ||||||
| タイトル | 受精鶏卵漿尿膜法を用いた悪性脳腫瘍に対する抗癌剤感受性試験 | |||||
| タイトル | ||||||
| タイトル | Chemosensitivity Test of Malignant Brain Tumors Using the Chick Embryo | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | chemosensitivity test | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | chorioallantoic membrane | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | chick embryo | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | malignant brain tumor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | brain metastasis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ID登録 | ||||||
| ID登録 | 10.24517/00017876 | |||||
| ID登録タイプ | JaLC | |||||
| 著者 |
円角, 文英
× 円角, 文英 |
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| 著者別表示 |
Enkaku, Fumihide
× Enkaku, Fumihide |
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| 書誌情報 |
金沢大学十全医学会雑誌 巻 100, 号 6, p. 1113-1127, 発行日 1991-12-20 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0022-7226 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00044397 | |||||
| 出版者 | ||||||
| 出版者 | 金沢大学十全医学会 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Multi-modality treatment including surgery, irradiation and chemotherapy is required for patients with malignant brain tumors which invade into surrounding tissue. On the other hand, for treatment of patients with metastatic brain tumors, which indicates advanced cancer, surgery and irradiation are mainly performed since the response rate to chemotherapy is low. To improve the prognosis of patients with cancer, many chemosensitivity tests, either in vitro or in vivo, have been tried to predict the efficacy of anticancer agents in individual patients before administration. However, no test that possesses high reproducibility, rapidity, convenience, low cost and good predictability has been developed so far. In this study, the usefulness of the chick embryo assay as an in vivo chemosensitivity test and also as an experimental model for brain metastasis was evaluated. First, rat C6 glioma cells were grafted on the Chorioallantoic membrane (CAM) of chick embryo. This grafting was used to examine the effect of anticancer drugs. Then, 67 surgical specimens including benign tumors were examined by this method. All the tumor specimens tested had been grafted on the CAM ; the evaluable ratio was 100%. Effectiveness ratios of ACNU, MCNU and CAP therapy for 22 specimens of glioblastoma, were 30.0, 50.0 and 18.8%, respectively. Effectiveness ratios for 7 specimens of anaplastic astrocytoma, were 28.6, 42.9 and 14.3%, respectively. Among them, 23 instances of previously untreated malignant glioma were. evaluated retrospectively to predict the clinical effects, judged by computed tomography. There were 6 (55%) instances in which the assay response correctly corresponded to a clinical response (true-positive). There were 5 (45%) false-positives for the assay, 0 (0%) false-negative and 12 (100%) true-negatives. The overall predictive accuracy was 78% (18/23). Thus, a high-degree of positive association exists between this assay and the clinical outcome. Moreover, as an experimental model for brain metastasis, murine B16-F10 melanoma cells were transplanted into the blood vessel on the CAM and the antitumor effects of ACNU, MCNU and CAP therapy on metastasi加d melanoma cells in the brains of chick embryos were examined. The drugs which passed through the blood-brain barrier, were effective in this assay system. These results indicate that this in vivo assay system using the chick embryo is a promising method in predicting clinical response in the treatment of malignant brain tumors and is also is a useful experimental model for brain metastasis. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
