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Plasma cholesteryl ester transfer protein (CETP) in relation to human pathophysiology
http://hdl.handle.net/2297/48573
http://hdl.handle.net/2297/4857325fba1fa-7252-4faf-a716-36296ebcbf6c
名前 / ファイル | ライセンス | アクション |
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ME-PR-INAZU-A-35.pdf (405.2 kB)
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Item type | 図書 / Book(1) | |||||
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公開日 | 2017-10-04 | |||||
タイトル | ||||||
タイトル | Plasma cholesteryl ester transfer protein (CETP) in relation to human pathophysiology | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_2f33 | |||||
資源タイプ | book | |||||
著者 |
Inazu, Akihiro
× Inazu, Akihiro |
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書誌情報 |
The HDL Handbook 巻 2010, p. 35-59, 発行日 2010-01-01 |
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ISBN | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | ISBN | |||||
関連識別子 | 978-012382171-3 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/B978-0-12-382171-3.10003-8 | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Plasma CETP was initially isolated as a highly purified 74 kD protein. The human CETP gene is located at chromosome 16q13, near the locus of the lecithin cholesterol acyltransferase (LCAT) gene. The CETP gene consists of 16 exons, spanning 25 kb. The CETP mRNA encodes 476 amino acids. The mature CETP contains four N-linked sugars with a variable glycosylation site of 341Asn. CETP mRNA is expressed in various tissues, but liver cells, adipocytes, and macrophages are abundant sources. One of the determinants of high density lipoprotein (HDL) neutral lipid composition is plasma CETP. In incubated human plasma, transfer and equilibration of (LCAT)-generated cholesteryl ester (CE) is found. Humans, hamsters, guinea pigs, and chickens belong to a group with intermediate CETP activity. Plasma CETP binds neutral lipids CE or triglyceride (TG), and phospholipid (PL) on HDL3, but CETP selectively promotes an exchange of CE and TG among lipoproteins. On the one hand, HDL-TG can be hydrolyzed by hepatic lipase, and on the other hand, plasma CETP decreases HDL particle size via CE/TG exchange between chylomicron/VLDL and HDL. Thus, CETP thereby accelerates the catabolic rate of HDL apolipoproteins. CETP enhances HDL remodeling from large HDL to small subclasses including pre-HDL. However, CETP deficiency would decrease cholesterol esterification rate, thereby inhibiting maturation of preb-HDL to α-migrating spherical HDL. Therefore, in CETP deficiency, large-to-small HDL remodeling is decreased and preb-HDL catabolism is also decreased. © 2010 Elsevier Inc. All rights reserved. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | [Book Chapter] | |||||
権利 | ||||||
権利情報 | Copyright © 2010 Elsevier Inc. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |