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個別薬物療法のための血漿中蛋白非結合型Disopyramide濃度測定の有用性
http://hdl.handle.net/2297/6725
http://hdl.handle.net/2297/6725e4bcb1fa-78b1-4d7d-8431-da1f12c02bcb
名前 / ファイル | ライセンス | アクション |
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HO-PR-MIYAMOTO-K-1.pdf (842.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | 個別薬物療法のための血漿中蛋白非結合型Disopyramide濃度測定の有用性 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Evidence for the Usefulness of Unbound Plasma Concentration of Disopyramide in Individual Anti-Arrhythmic Therapy | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
大川, 浩子
× 大川, 浩子× 渡辺, 真生× 斎藤, 義正× 打和, 寿子× 藤井, 奨× 井野, 秀一× 横川, 弘一× 宮本, 謙一 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医学部附属病院薬剤部 | |||||
書誌情報 |
臨床薬理 巻 34, 号 1, p. 1-6, 発行日 2003-01-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0388-1601 | |||||
出版者 | ||||||
出版者 | 日本臨床薬理学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The unbound concentration of disopyramide (DP) in plasma was studied to determine whether or not it is a useful index to assess the effectiveness of DP in anti-arrhythmic therapy. In 20 arrhythmic patients administered DP (Rythmodan®, 100-600 mg/day), there was no correlation between the dose and total or unbound plasma concentration of DP. The values of unbound fraction (fp) of DP in plasma widely varied from 0.25 to 0.57. The fp values were not correlated with the albumin concentration in plasma, but did correlate with the concentration of α1-acid glycoprotein. We further examined the relationship between the total or unbound plasma concentrations of DP and it's effectiveness in 16 of the 20 patients (4 patients had side effects). There was significant difference in the plasma concentrations of DP between the effective group and the ineffective group. However, as the range of the concentration for the two groups overlapped in 75%, the total concentration cannot be used to define the effectiveness. On the other hand, the unbound concentration of DP was greater than 0.8 μg/mL in the effective group, whereas it was lower than 0.8 μg/ mL in the ineffective group. There was no correlation between the unbound concentration of mono-N-dealkyldisopyramide (MND) and the effectiveness. The range of the unbound plasma concentration of MND was 0.1-1.0 μg/mL, and no patient developed side effects such as tachycardia or constipation due to the anticholinergic effect. In conclusion, an unbound concentration of DP in plasma of over 0.8 μg/mL can be used as an index of the effectiveness of anti-arrhythmic therapy in therapeutic drug monitoring. | |||||
権利 | ||||||
権利情報 | Copyright (c) 2003 日本臨床薬理学会 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.jscpt.jp/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://sciencelinks.jp/j-east/article/200309/000020030903A0216642.php |