| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-05 |
| タイトル |
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タイトル |
Promotion of rabbit ligament healing by local delivery of hepatocyte growth factor |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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ID登録 |
10.24517/00026755 |
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ID登録タイプ |
JaLC |
| 著者 |
Ueshima, Kenichi
Kitaoka, Katsuhiko
Nakase, Junsuke
Xu, Qing
松本, 邦夫
Tsuchiya, Hiroyuki
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| 著者別表示 |
北岡, 克彦
中瀬, 順介
松本, 邦夫
土屋, 弘行
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| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学附属病院 |
| 書誌情報 |
Journal of Orthopaedic Science
巻 16,
号 4,
p. 451-457,
発行日 2011-07-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0949-2658 |
| NCID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11052566 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1007/s00776-011-0101-z |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Extracapsular ligament injuries of the knee and ankle are common injuries. Ligaments heal slowly, usually over months or longer by scar formation rather than by tissue regeneration. This study was performed to evaluate the therapeutic effect of locally delivered recombinant hepatocyte growth factor (HGF) on the early healing of ligaments in a rabbit model. Methods: Japanese white rabbits were subjected to a standardized gap injury in the medial collateral ligaments (MCLs) of both knees. Each rabbit underwent bilateral transection of the midsubstance of the MCL, which was not repaired. During postoperative days 0-6, the rabbits were injected with 10 μg human recombinant HGF into the right MCL, while the left MCL was injected with saline alone. One, 3, 6, and 12 weeks after surgery, experimental rabbits were sacrificed. The structural properties of the femur-MCL-tibia complex were then assessed and the tissue was subjected to histological evaluation. To see the distribution of cells that express c-Met receptor, the tissue was subjected to immunohistochemistry. Results: Immunohistochemical evaluation revealed that c-Met expression was observed particularly at opposing ligament ends in the HGF-treated limbs 1 week after surgery. Histological evaluation revealed earlier neovascularization and more aligned collagen fibers in the MCLs of the HGF-treated group than the control group. In mechanical evaluations, similar ligament failure modes were noted in the two groups. After 3 weeks, HGF-treated limbs had significantly improved structural properties than the paired control limbs. Conclusions: Our findings indicate local administration of recombinant HGF promotes early steps in ligament healing and the repair of structural properties in a rabbit model. Local administration of HGF may represent a new therapeutic approach to accelerating healing and rehabilitation after ligament injury. © 2011 The Japanese Orthopaedic Association. |
| 著者版フラグ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
http://www.springerlink.com/content/727j488x8njw34u7/ |
ME-PR-UESHIMA-K-451.pdf (3.8 MB)
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