| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-05 |
| タイトル |
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タイトル |
Repair of segmental bone defects in rabbit tibia promoted by a complex of β-tricalcium phosphate and hepatocyte growth factor |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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ID登録 |
10.24517/00026824 |
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ID登録タイプ |
JaLC |
| 著者 |
Goshima, Kenichi
Nakase, Junsuke
Xu, Qing
松本, 邦夫
Tsuchiya, Hiroyuki
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| 著者別表示 |
五嶋, 謙一
中瀬, 順介
松本, 邦夫
土屋, 弘行
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| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学附属病院 |
| 書誌情報 |
Journal of Orthopaedic Science
巻 17,
号 5,
p. 639-648,
発行日 2012-09-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0949-2658 |
| NCID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11052566 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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|
関連識別子 |
10.1007/s00776-012-0262-4 |
| 出版者 |
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出版者 |
日本臨床整形外科学会 = Japanese Orthopaedic Association / Springer |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Segmental bone defect repair remains a clinical and scientific challenge with increasing interest focused on bone tissue engineering. Clinical studies are ongoing to address application of hepatocyte growth factor (HGF) for treatment of some diseases; however, the use of HGF in bone tissue engineering has not been addressed. This study was performed to evaluate the effect of HGF in a complex of β-tricalcium phosphate (β-TCP) and collagen in repairing segmental bone defects. Methods: Segmental bone defects 5 mm long were created in the middle of the tibial shafts of rabbits. The defect was stabilized with external fixators and implanted with a complex of β-TCP granules and collagen, with or without 100 μg recombinant human HGF. Biweekly, bone regeneration and β-TCP resorption were assessed radiographically and histologically. At 4 and 8 weeks, bone regeneration was evaluated by use of micro-computed tomography and mechanical tests. Results: Compared with the bone tissue treated with β-TCP and collagen, mineralization, angiogenesis, new bone formation, and absorption of β-TCP were promoted 4 weeks postoperatively by treatment with HGF in the β-TCP and collagen group. These changes were associated with promoting biomechanical regeneration. By 8 weeks, the formation of bone marrow in newly generated bone and absorption of the β-TCP granules were completed in a shorter period by combining HGF with β-TCP and collagen, compared with tissues without HGF. Conclusions: The combined application of HGF in a β-TCP and collagen matrix promoted histological bone healing and augmented mechanical strength of the healing bone, particularly in the early stages. The combined use of HGF and β-TCP for treatment of bone defects made a substantial difference. © The Japanese Orthopaedic Association 2012. |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
http://www.joa.or.jp/jp/index.html |
HO-PR-NAKASE-J-639.pdf (938.0 kB)
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