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  1. G. 附属病院
  2. g 10. 学術雑誌掲載論文
  3. 1. 査読済論文

Assessment of Coronary atherosclerosis in patients with familial hypercholesterolemia by coronary computed tomography angiography

http://hdl.handle.net/2297/41369
http://hdl.handle.net/2297/41369
5ab1a901-da72-4073-8aaf-4f00b2f98c20
名前 / ファイル ライセンス アクション
HO-PR-TADA-H-724.pdf HO-PR-TADA-H-724.pdf (792.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-10-05
タイトル
タイトル Assessment of Coronary atherosclerosis in patients with familial hypercholesterolemia by coronary computed tomography angiography
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Tada, Hayato

× Tada, Hayato

WEKO 513
e-Rad 90623653
金沢大学研究者情報 90623653
研究者番号 90623653

Tada, Hayato

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Kawashiri, Masa-aki

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WEKO 333
e-Rad 90345637
金沢大学研究者情報 90345637
研究者番号 90345637

Kawashiri, Masa-aki

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Okada, Hirofumi

× Okada, Hirofumi

WEKO 45532

Okada, Hirofumi

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Teramoto, Ryota

× Teramoto, Ryota

WEKO 25047
研究者番号 90735169

Teramoto, Ryota

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Konno, Tetsuo

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WEKO 20207
e-Rad 50377389
金沢大学研究者情報 50377389
研究者番号 50377389

Konno, Tetsuo

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Yoshimuta, Tsuyoshi

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研究者番号 10574618

Yoshimuta, Tsuyoshi

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Sakata, Kenji

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WEKO 22733
金沢大学研究者情報 20456411
研究者番号 20456411

Sakata, Kenji

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Nohara, Atsushi

× Nohara, Atsushi

WEKO 342
e-Rad 50313648
金沢大学研究者情報 50313648
研究者番号 50313648

Nohara, Atsushi

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Inazu, Akihiro

× Inazu, Akihiro

WEKO 539
e-Rad 80293348
金沢大学研究者情報 80293348
研究者番号 80293348

Inazu, Akihiro

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Kobayashi, Junji

× Kobayashi, Junji

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e-Rad 60302577

Kobayashi, Junji

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Mabuchi, Hiroshi

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WEKO 389
e-Rad 00019960
研究者番号 00019960

Mabuchi, Hiroshi

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Yamagishi, Masakazu

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WEKO 265
e-Rad 70393238
金沢大学研究者情報 70393238
研究者番号 70393238

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Hayashi, Kenshi

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WEKO 266
e-Rad 00422642
金沢大学研究者情報 00422642
研究者番号 00422642

Hayashi, Kenshi

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書誌情報 American Journal of Cardiology

巻 115, 号 6, p. 724-729, 発行日 2015-03-15
ISSN
収録物識別子タイプ ISSN
収録物識別子 0002-9149
NCID
収録物識別子タイプ NCID
収録物識別子 AA00048410
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1016/j.amjcard.2014.12.034
出版者
出版者 Elsevier
抄録
内容記述タイプ Abstract
内容記述 The aims of this study were (1) to determine whether the accumulation of coronary plaque burden assessed with coronary computed tomography angiography (CCTA) can predict future events and (2) to estimate the onset and progression of coronary atherosclerosis in patients with familial hypercholesterolemia (FH). Consecutive 101 Japanese patients with heterozygous FH (men= 52, mean age 56 ± 16years, mean low-density lipoprotein cholesterol 264 ± 58mg/dl) who underwent 64-detector row CCTA without known coronary artery disease were retrospectively evaluated by assigning a score (0 to 5) to each of 17 coronary artery segments according to the Society of Cardiovascular Computed Tomography guidelines. Those scores were summed and subsequently natural log transformed. The periods to major adverse cardiac events (MACE) were estimated using multivariable Cox proportional hazards models. During the follow-up period (median 941days), 21 MACE had occurred. Receiver operating characteristic curve analyses identified a plaque burden score of 3.35 (raw score 28.5) as the optimal cutoff for predicting a worse prognosis. Multivariate Coxregression analysis identified the presence of a plaque score ≥3.35 as a significant independent predictor of MACE (hazard ratio= 3.65; 95% confidence interval 1.32 to 25.84, p<0.05). The regression equations were Y= 0.68. X- 15.6 (r= 0.54, p <0.05) in male and Y= 0.74. X- 24.8 (r= 0.69, p <0.05) in female patients with heterozygous FH. In conclusion, coronary plaque burden identified in a noninvasive, quantitative manner was significantly associated with future coronary events in Japanese patients with heterozygous FH and that coronary atherosclerosis may start to develop, on average, at age 23 and 34years in male and female patients with heterozygous FH, respectively.
著者版フラグ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
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