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Response to chemotherapy improves hepatic reserve for patients with hepatocellular carcinoma and Child–Pugh B cirrhosis
https://doi.org/10.24517/00026915
https://doi.org/10.24517/00026915651c96ba-848e-41b5-af7b-fc2be9b5fc06
| 名前 / ファイル | ライセンス | アクション |
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HO-PR-TERASHIMA-T-1263.pdf (412.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2017-10-05 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Response to chemotherapy improves hepatic reserve for patients with hepatocellular carcinoma and Child–Pugh B cirrhosis | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| ID登録 | ||||||||||||||||||||||||
| ID登録 | 10.24517/00026915 | |||||||||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||||||||
| 著者 |
Terashima, Takeshi
× Terashima, Takeshi× Yamashita, Tatsuya× Arai, Kuniaki× Kawaguchi, Kazunori× Kitamura, Kazuya× Yamashita, Taro× Sakai, Yoshio× Mizukoshi, Eishiro× Honda, Masao× Kaneko, Shuichi |
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| 著者別表示 |
寺島, 健志
× 寺島, 健志
× 山下, 竜也
× 荒井, 邦明
× 北村, 和哉
× 山下, 太郎
× 酒井, 佳夫
× 水腰, 英四郎
× 本多, 政夫
× 金子, 周一
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| 提供者所属 | ||||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | 金沢大学先進予防医学研究センター / 金沢大学附属病院 | |||||||||||||||||||||||
| 書誌情報 |
Cancer Science 巻 107, 号 9, p. 1263-1269, 発行日 2016-09-01 |
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| ISSN | ||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 1347-9032 | |||||||||||||||||||||||
| NCID | ||||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA11808050 | |||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | 10.1111/cas.12992 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Japanese Cancer Association / Blackwell Publishing Ltd | |||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | There is no established treatment for patients with advanced hepatocellular carcinoma (HCC) with Child–Pugh class B cirrhosis. The aim of the present study was to assess the efficacy of hepatic arterial infusion chemotherapy (HAIC) according to Child–Pugh score (CPS) and to evaluate the correlation of a patient's response to HAIC with hepatic reserve and outcome. We retrospectively reviewed the medical records of 377 patients treated with HAIC between March 2003 and February 2015. Subjects included 179 with Child–Pugh class B. Median overall survival was 12.1 months for patients with CPS = 7 (n = 75) and 11.9 months for patients with CPS = 8 (n = 58), which were significantly longer compared with those of patients with CPS = 9 (n = 46, 6.3 months). The objective response rates of patients with CPS = 7, 8 and 9 were 26.7%, 27.6% and 6.5%, respectively. The CPS of responders improved significantly after HAIC, whereas those of nonresponders did not. A multivariate analysis demonstrated that improved CPS, responses to HAIC and absence of extrahepatic lesions were independent favorable prognostic factors. Patients with CPS = 7 or 8 tolerated HAIC, but nine (19.6%) of patients with CPS = 9 were unable to complete one course. HAIC is effective and safe for patients with a CPS = 7 or 8 and improved hepatic reserve of responders significantly. © 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. | |||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||
| 権利情報 | © Japanese Cancer Association 日本癌学会 | |||||||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| 関連URI | ||||||||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||||||||
| 関連識別子 | http://www.jca.gr.jp/ | |||||||||||||||||||||||
