| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-05 |
| タイトル |
|
|
タイトル |
Decreased levels of regulatory B cells in patients with systemic sclerosis: Association with autoantibody production and disease activity |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00026939 |
|
ID登録タイプ |
JaLC |
| 著者 |
Matsushita, Takashi
Hamaguchi, Yasuhito
Hasegawa, Minoru
Takehara, Kazuhiko
Fujimoto, Manabu
|
| 著者別表示 |
松下, 貴史
濱口, 儒人
長谷川, 稔
竹原, 和彦
藤本, 学
|
| 書誌情報 |
Rheumatology (United Kingdom)
巻 55,
号 2,
p. 263-267,
発行日 2015-10-05
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1462-0324 |
| NCID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11316191 |
| DOI |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1093/rheumatology/kev331 |
| 出版者 |
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|
出版者 |
Oxford University Press |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Objective. B cell abnormalities characterized by autoantibody production and polyclonal B cell activation play an important role in the pathogenesis of SSc. IL-10 producing regulatory B (Breg) cells also play an important role in the negative immune response. We identified a human Breg cell subset that was predominantly found within the CD24hiCD27+ B cell subpopulation. However, the role of Breg cells in SSc remains unknown. The aim of this study was to investigate the clinical association of Breg cells in SSc patients. Methods. Blood IL-10 producing Breg cell levels were determined by FACS in 35 SSc patients and 30 healthy subjects. In a follow-up study, we analysed six individual dcSSc patients before and after treatment. Results. The frequency of blood Breg cells was significantly lower in SSc patients than in healthy controls (P<0.0001). Similarly, the frequency of CD24hiCD27+ B cells was significantly lower in SSc patients than in healthy controls (P<0.0001). SSc patients with decreased Breg cell levels often had interstitial lung disease (P<0.05). Furthermore, Breg cell levels correlated negatively with the titre of anti-topo I antibody (Ab) and anticentromere Ab in SSc patients. For a follow-up study, Breg cell levels in dcSSc patients after treatment were found to be significantly increased compared with those before treatment (P<0.05), accompanied by decreased disease activity. Thus, Breg cell levels were inversely correlated with disease activity of SSc. Conclusion. These results suggest that decreased Breg cell levels may contribute to the development of SSc. © The Author 2015. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Embargo Period 12 months |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
HO-PR-MATSUSHITA-T-263.pdf (322.2 kB)
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