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Clinical characteristics of acromegalic patients with empty sella and their outcomes following transsphenoidal surgery
https://doi.org/10.24517/00026943
https://doi.org/10.24517/00026943a6dce167-4198-4107-8e95-68c70cebaf11
| 名前 / ファイル | ライセンス | アクション |
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HO-PR-SASAGAWA-Y-403.pdf (270.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2017-11-09 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Clinical characteristics of acromegalic patients with empty sella and their outcomes following transsphenoidal surgery | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| ID登録 | ||||||||||||||||||||
| ID登録 | 10.24517/00026943 | |||||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||||
| 著者 |
Sasagawa, Yasuo
× Sasagawa, Yasuo× Tachibana, Osamu× Doai, Mariko× Hayashi, Yasuhiko× Tonami, Hisao× Iizuka, Hideaki× Nakada, Mitsutoshi |
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| 著者別表示 |
笹川, 泰生
× 笹川, 泰生
× 立花, 修
× 道合, 万里子
× 林, 康彦
× 利波, 久雄
× 飯塚, 秀明
× 中田, 光俊
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| 書誌情報 |
Pituitary 巻 20, 号 4, p. 403-408, 発行日 2017-08-01 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 1386-341X | |||||||||||||||||||
| NCID | ||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA11488255 | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | 10.1007/s11102-017-0798-6 | |||||||||||||||||||
| 出版者 | ||||||||||||||||||||
| 出版者 | Springer | |||||||||||||||||||
| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Purpose: To analyze the clinical characteristics of acromegalic patients with empty sella (ES, herniation of the subarachnoid space within the sella turcica) and the impact of ES on transsphenoidal surgery in such patients. Methods: Seventy-eight patients, newly diagnosed with acromegaly who underwent transsphenoidal surgery were included. ES was defined as the pituitary gland and adenoma occupying less than 50% of the sella turcica on midsagittal magnetic resonance (MR) imaging. Results: Twelve patients (15.4%), predominantly female (10 women, p = .047), had ES in preoperative MR imaging. ES patients had smaller mean tumor diameter (6.3 mm) than non-ES patients (11.2 mm, p = .001). In preoperative MR imaging, occult adenoma was found in three (25%) ES and three (4.5%) non-ES patients (p = .044). Intraoperative cerebrospinal fluid (CSF) leakage was more frequent in the ES patients than in the non-ES patients (58.3 vs. 25.8%, p = .024). This led to an increased rate of sellar floor reconstruction using abdominal fat and/or postoperative lumber drainage in the ES patients (ES: 41.7 vs. non-ES: 16.7%, p = .063). Endocrinological remission after surgery was more frequent in the non-ES patients (72.7%) than in the ES patients (58.3%) (p = .248). Conclusions: Co-existence of acromegaly with ES is not rare, and is associated with occult adenoma, intra/postoperative CSF leakage, and a worse endocrinological outcome after transsphenoidal surgery; although, the underlying mechanism remains unclear. © 2017 Springer Science+Business Media New York | |||||||||||||||||||
| 内容記述 | ||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||
| 内容記述 | Embargo Period 12 months | |||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||
