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The crude extract from puerariae flower exerts antiobesity and antifatty liver effects in high-fat diet-induced obese mice
http://hdl.handle.net/2297/39146
http://hdl.handle.net/2297/39146711d246f-6126-497e-a05a-52dea6190888
名前 / ファイル | ライセンス | アクション |
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PH-PR-SHIMADA-T-272710.pdf (2.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | The crude extract from puerariae flower exerts antiobesity and antifatty liver effects in high-fat diet-induced obese mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kamiya, Tomoyasu
× Kamiya, Tomoyasu× Sameshima-Kamiya, Mayu× Nagamine, Rika× Tsubata, Masahito× Ikeguchi, Motoya× Takagaki, Kinya× Shimada, Tsutomu× Aburada, Masaki |
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書誌情報 |
Evidence-based Complementary and Alternative Medicine 巻 2012, p. 272710, 発行日 2012-01-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1741-427X | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11968793 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1155/2012/272710 | |||||
出版者 | ||||||
出版者 | Hindawi Publishing Corporation | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Kudzu, a leguminous plant, has long been used in folk medicine. In particular, its flowers are used in Japanese and Chinese folk medicine for treating hangovers. We focused on the flower of Kudzu (Puerariae thomsonii), and we previously reported the antiobesity effect of Puerariae thomsonii flower extract (PFE) in humans. In this study, we conducted an animal study to investigate the effect of PFE on visceral fat and hepatic lipid levels in mice with diet-induced obesity. In addition, we focused on gene expression profiles to investigate the antiobesity mechanism of PFE. Male C57BL/6J mice were fed a high-fat diet (HFD) or an HFD supplemented with 5% PFE for 14 days. PFE supplementation significantly reduced body weight and white adipose tissue (WAT) weight. Moreover, in the histological analysis, PFE supplementation improved fatty liver. Hepatic reverse transcription-polymerase chain reaction revealed that PFE supplementation downregulated acetyl-CoA carboxylase expression. For adipose tissue, the expressions of hormone-sensitive lipase in WAT and uncoupling protein 1 in brown adipose tissue (BAT) were significantly upregulated. These results suggest that PFE exerts antiobesity and antifatty liver effects in high-fat diet-induced obese mice through suppressing lipogenesis in the liver, stimulating lipolysis in WAT, and promoting thermogenesis in BAT. Copyright © 2012 Tomoyasu Kamiya et al. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
権利 | ||||||
権利情報 | Copyright © 2012 Tomoyasu Kamiya et al. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |