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  1. G. 附属病院
  2. g 10. 学術雑誌掲載論文
  3. 1. 査読済論文

Morphine glucuronosyltransferase activity in human liver microsomes is inhibited by a variety of drugs that are co-administered with morphine.

https://doi.org/10.24517/00027014
https://doi.org/10.24517/00027014
b52b0dfe-a424-4c57-9d48-ee91ba934883
名前 / ファイル ライセンス アクション
HO-PR-HARA-Y-103.pdf HO-PR-HARA-Y-103.pdf (412.0 kB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-10-05
タイトル
タイトル Morphine glucuronosyltransferase activity in human liver microsomes is inhibited by a variety of drugs that are co-administered with morphine.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
ID登録
ID登録 10.24517/00027014
ID登録タイプ JaLC
著者 Hara, Yusuke

× Hara, Yusuke

WEKO 109891

Hara, Yusuke

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Nakajima, Miki

× Nakajima, Miki

WEKO 196
e-Rad 70266162
金沢大学研究者情報 70266162
研究者番号 70266162

Nakajima, Miki

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Miyamoto, Ken-ichi

× Miyamoto, Ken-ichi

WEKO 22059
研究者番号 30100514

Miyamoto, Ken-ichi

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Yokoi, Tsuyoshi

× Yokoi, Tsuyoshi

WEKO 63
研究者番号 70135226

Yokoi, Tsuyoshi

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著者別表示 原, 祐輔

× 原, 祐輔

原, 祐輔

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中嶋, 美紀

× 中嶋, 美紀

中嶋, 美紀

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宮本, 謙一

× 宮本, 謙一

宮本, 謙一

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横井, 毅

× 横井, 毅

横井, 毅

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提供者所属
内容記述タイプ Other
内容記述 金沢大学附属病院薬剤部
書誌情報 Drug metabolism and pharmacokinetics

巻 22, 号 2, p. 103-112, 発行日 2007-04-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 1347-4367
NCID
収録物識別子タイプ NCID
収録物識別子 AA1162652X
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.2133/dmpk.22.103
出版者
出版者 日本薬物動態学会=Japanese Society for the Study of Xenobiotics (JSSX)
抄録
内容記述タイプ Abstract
内容記述 Morphine is an analgesic drug used for the treatment of acute and chronic pain syndromes for cancer patients. Glucuronidation is a major pathway of the elimination of morphine in humans. Morphine is metabolized to 3-glucuronide (no analgesic effect) and 6-glucuronide (more potently analgesic than morphine) mainly by UGT2B7. In the present study, we investigated the inhibitory effects of a variety of drugs on the morphine glucuronosyltransferase activities in human liver microsomes. Twenty-one drugs including anticancer drugs, immunosuppressants, analgesics, anticonvulsants, antidepressants, antipsychotic drugs were selected in this study, because they are frequently co-administered with morphine. We found that 10 out of 21 drugs, tamoxifen, tacrolimus, diclofenac, carbamazepine, imipramine, clomipramine, amitriptyline, diazepam, lorazepam and oxazepam extensively inhibited the morphine 3- and 6-glucuronosyltransferase activities. Although some of the drugs are not substrates of UGT2B7, they would be potent inhibitors of UGT2B7. If patients receive morphine and these drugs simultaneously, the drug-drug interaction may change the levels of morphine and these glucuronides, resulting in altered analgesic efficacy and the risk of side effects. The results presented here will assist clinicians in choosing the proper drugs and/or dosages, and enable them to anticipate potential drug-drug interactions.
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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