{"_buckets": {"deposit": "1d68095f-0e27-4710-9c3d-de8e7168aea9"}, "_deposit": {"created_by": 3, "id": "27037", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "27037"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00027037", "sets": ["1763"]}, "author_link": ["22059", "45867", "45864", "45868", "45865", "45869", "45866"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-11-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "1501", "bibliographicPageStart": "1497", "bibliographicVolumeNumber": "58", "bibliographic_titles": [{"bibliographic_title": "Chemical and Pharmaceutical Bulletin"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Kampo medicines, traditional herbal medicines in Japan, are comprised of multiple botanical raw materials that contain a number of pharmacologically active substances. Conventionally, the quality control of kampo medicines has been performed by analyzing the contents of two or three representative components. However, it is not sufficient to check quality only with a limited number of specific components. We performed HPLC of 287 lots of keishibukuryogan formulas, calculated the areas of 11 components on chromatograms as feature values and made a cluster analysis using self-organizing maps (SOMs). We verified the precision (repeatability and intermediate precision) of clustering results when using the same samples and successfully established an clustering method using SOMs that is capable of precisely clustering differences in HPLC-fingerprints among pharmaceutical manufacturers, differences in HPLC-fingerprints due to the combination ratios of botanical raw materials, and differences in HPLC-fingerprints due to changes in component contents caused by time-course deterioration. Consequently, we could confirm that this method is useful for controlling the quality of multiple component drugs and analyzing quality differences. © 2010 Pharmaceutical Society of Japan.", "subitem_description_type": "Abstract"}]}, "item_4_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学附属病院薬剤部", "subitem_description_type": "Other"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Pharmaceutical Society of Japan = 日本薬学会"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1248/cpb.58.1497", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.jstage.jst.go.jp/article/cpb/58/11/58_1497/_article", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "(c) 2010 The Pharmaceutical Society of Japan"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00602100", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0009-2363", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Satomi, Hisanori"}], "nameIdentifiers": [{"nameIdentifier": "45864", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori, Yoshikazu"}], "nameIdentifiers": [{"nameIdentifier": "45865", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Makino, Bunsho"}], "nameIdentifiers": [{"nameIdentifier": "45866", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakai, Youichiro"}], "nameIdentifiers": [{"nameIdentifier": "45867", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeda, Shuichi"}], "nameIdentifiers": [{"nameIdentifier": "45868", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aburada, Masaki"}], "nameIdentifiers": [{"nameIdentifier": "45869", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyamoto, Kenichi"}], "nameIdentifiers": [{"nameIdentifier": "22059", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30100514", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030100514"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PH-PR-MIYAMOTO-K-1497.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1800000.0, "url": {"label": "PH-PR-MIYAMOTO-K-1497.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/27037/files/PH-PR-MIYAMOTO-K-1497.pdf"}, "version_id": "3ca70249-5d28-4d22-abf7-5f6aab538246"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Fingerprint", "subitem_subject_scheme": "Other"}, {"subitem_subject": "High-performance liquid chromatography", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Kampo medicine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Keishibukuryogan", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Quality control", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Self-organizing map", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Clustering analysis of Keishibukuryogan formulas by use of self-organizing maps", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Clustering analysis of Keishibukuryogan formulas by use of self-organizing maps"}]}, "item_type_id": "4", "owner": "3", "path": ["1763"], "permalink_uri": "http://hdl.handle.net/2297/25780", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-05"}, "publish_date": "2017-10-05", "publish_status": "0", "recid": "27037", "relation": {}, "relation_version_is_last": true, "title": ["Clustering analysis of Keishibukuryogan formulas by use of self-organizing maps"], "weko_shared_id": -1}