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Effect of thalidomide on endotoxin-induced decreases in activity and expression of hepatic cytochrome P450 3A2
http://hdl.handle.net/2297/11552
http://hdl.handle.net/2297/11552038341dd-1add-4548-92db-86b6114cfc3e
名前 / ファイル | ライセンス | アクション |
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PH-PR-MIYAMOTO-K-1596.pdf (786.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Effect of thalidomide on endotoxin-induced decreases in activity and expression of hepatic cytochrome P450 3A2 | |||||
言語 | ||||||
言語 | eng | |||||
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資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ueyama, Jun
× Ueyama, Jun× Nada, Masayuki× Zhao, Ying Lan× Kanazawa, Hiroyuki× Takagi, Kenji× Kondo, Takaaki× Takagi, Kenzo× Wakusawa, Shinya× Abe, Fumie× Saito, Hiroko× Miyamoto, Ken-ichi× Hasegawa, Takaaki |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院薬剤部 | |||||
書誌情報 |
Biological and Pharmaceutical Bulletin 巻 31, 号 8, p. 1596-1600, 発行日 2008-08-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0918-6158 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.31.1596 | |||||
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出版者 | 日本薬学会 | |||||
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内容記述タイプ | Abstract | |||||
内容記述 | Thalidomide has been reported to inhibit the production of tumor necrosis factor-alpha (TNF-α) and nitric oxide (NO) that are involved in the down-regulation of hepatic cytochrome P450 (CYP) induced by endotoxin. In the present study, we investigated the effects of thalidomide on endotoxin-induced decreases in the activity and expression of hepatic CYP3A2 in rats. Thalidomide (50 mg/kg) was administered orally 22 h and 2 h before intraperitoneal injection of endotoxin (1 mg/kg). Twenty-four hours after the injection of endotoxin, antipyrine clearance experiments were conducted, in which the rats were sacrificed and protein levels of hepatic CYP3A2 were measured. There were no significant differences in the histopathological changes in the liver between the endotoxin-treated and endotoxin plus thalidomide-treated rats. Thalidomide had no effect on the systemic clearance of antipyrine, which is a proper indicator for hepatic CYP3A2 activity, whereas it enhanced endotoxin-induced decrease in the systemic clearance of antipyrine. Western blot analysis revealed that thalidomide had no effect on the protein levels of hepatic CYP3A2, whereas it enhanced the down-regulation of hepatic CYP3A2 by endotoxin. However, there were no significant differences in the concentrations of TNF-α and NO in plasma between the endotoxin-treated and endotoxin plus thalidomide-treated rats. The present findings suggest that thalidomide enhances endotoxin-induced decreases in the activity and expression of hepatic CYP3A2. © 2008 Pharmaceutical Society of Japan. | |||||
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出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |