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Rad9 modulates the P21WAF1 pathway by direct association with p53
https://doi.org/10.24517/00027357
https://doi.org/10.24517/00027357182f24b1-e531-47c8-a8a8-2eb705ac9821
| 名前 / ファイル | ライセンス | アクション |
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CA-PR-KOBAYASHI-M-37.pdf (671.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2017-10-05 | |||||||||
| タイトル | ||||||||||
| タイトル | Rad9 modulates the P21WAF1 pathway by direct association with p53 | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.24517/00027357 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
Ishikawa, Kazuhiro
× Ishikawa, Kazuhiro× Ishii, Hideshi× Murakumo, Yoshiki× Mimori, Koshi× Kobayashi, Masahiko× Yamamoto, Ken-ichi× Mori, Masaki× Nishino, Hiroshi× Furukawa, Yusuke× Ichimura, Keiichi |
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| 著者別表示 |
小林, 昌彦
× 小林, 昌彦
× 山本, 健一
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| 提供者所属 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 金沢大学がん研究所がん分子細胞制御 | |||||||||
| 書誌情報 |
BMC Molecular Biology 巻 8, p. 37, 発行日 2007-04-21 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1471-2199 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1186/1471-2199-8-37 | |||||||||
| 出版者 | ||||||||||
| 出版者 | BioMed Central | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Background Previous studies suggest that human RAD9 (hRad9), encoding a DNA damage checkpoint molecule, which is frequently amplified in epithelial tumor cells of breast, lung, head and neck cancer, participates in regulation of the tumor suppressor p53-dependent transactivation of pro-survival P21WAF1. This study examined the exact mechanism of the hRad9 function, especially through the phosphorylation of the C-terminus, in the transcription regulation of P21WAF1. Results The transfection of phosphorylation-defective hRAD9 mutants of C-terminus resulted in reduction of the p53-dependent P21WAF1 transactivation; the knockdown of total hRad9 elicited an increased P21WAF1 mRNA expression. Immunoprecipitation and a ChIP assay showed that hRad9 and p53 formed a complex and both were associated with two p53-consensus DNA-binding sequences in the 5' region of P21WAF1 gene. The association was reduced in the experiment of phosphorylation-defective hRAD9 mutants. Conclusion The present study indicates the direct involvement of hRad9 in the p53-dependent P21WAF1 transcriptional mechanism, presumably via the phosphorylation sites, and alterations of the hRad9 pathway might therefore contribute to the perturbation of checkpoint activation in cancer cells. | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| シリーズ | ||||||||||
| 関連名称 | 37 | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://creativecommons.org/licenses/by/2.0/ | |||||||||
